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TOMM34 translocase of outer mitochondrial membrane 34 [ Homo sapiens (human) ]

Gene ID: 10953, updated on 27-Nov-2024

Summary

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Official Symbol
TOMM34provided by HGNC
Official Full Name
translocase of outer mitochondrial membrane 34provided by HGNC
Primary source
HGNC:HGNC:15746
See related
Ensembl:ENSG00000025772 MIM:616049; AllianceGenome:HGNC:15746
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOM34; URCC3; HTOM34P
Summary
The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 58.9), adrenal (RPKM 15.3) and 22 other tissues See more
Orthologs
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Genomic context

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See TOMM34 in Genome Data Viewer
Location:
20q13.12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (44942130..44960397, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (46677999..46696286, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43570771..43589038, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:43514076-43514692 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43545042-43545542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43545543-43546043 Neighboring gene poly(A) binding protein cytoplasmic 1 like Neighboring gene uncharacterized LOC124904912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12953 Neighboring gene STK4 divergent transcript Neighboring gene serine/threonine kinase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12954

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities. Durech M, et al. Mol Cell Proteomics, 2016 May. PMID 26944342, Free PMC Article
  2. High Expression of Tomm34 and Its Correlations With Clinicopathology in Oral Squamous Cell Carcinoma. Cai M, et al. Pathol Oncol Res, 2021. PMID 34257607, Free PMC Article
  3. Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target. Shimokawa T, et al. Int J Oncol, 2006 Aug. PMID 16820880
  4. TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome. Aleskandarany MA, et al. Breast Cancer Res Treat, 2012 Nov. PMID 23053644
  5. The interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors. Trcka F, et al. J Biol Chem, 2020 Jul 3. PMID 32371396, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of TOMM34 on NF-kappaB activation-related hyperinflammation in severely ill patients with COVID-19 and influenza.
    Title: Role of TOMM34 on NF-κB activation-related hyperinflammation in severely ill patients with COVID-19 and influenza.
  2. TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function.
    Title: TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function.
  3. High Expression of Tomm34 and Its Correlations With Clinicopathology in Oral Squamous Cell Carcinoma.
    Title: High Expression of Tomm34 and Its Correlations With Clinicopathology in Oral Squamous Cell Carcinoma.
  4. Expression of TOMM34 and Its Clinicopathological Correlations in Urothelial Carcinoma of the Bladder.
    Title: Expression of TOMM34 and Its Clinicopathological Correlations in Urothelial Carcinoma of the Bladder.
  5. The interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors.
    Title: The interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors.
  6. Translocase of outer mitochondrial membrane 34 (Tomm34) is commonly expressed at high levels in epithelial ovarian cancers, except for the clear cell and mucinous subtypes. The expression of Tomm34 is positively correlated with FIGO stage. Tomm34 levels also indicates poor prognosis and progression for patients with mutant p53.
    Title: Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.
  7. TOM34 and its partner HSP90AA1 might be used as a potential biomarker for monitoring HCV-induced hepatocellular carcinoma progression in the Egyptian population. Future large-scale validation studies are warranted.
    Title: Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study.
  8. Data show that Tomm34 extensively interacts with the C-terminal structures of Hsp70 selectively in its ATP-bound state and that this interaction is strongly entropically driven.
    Title: Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities.
  9. These results suggest that Tomm34 represents a novel scaffolding co-chaperone of Hsp70 and Hsp90, which may facilitate Hsp70/Hsp90 cooperation during protein folding
    Title: The assembly and intermolecular properties of the Hsp70-Tomm34-Hsp90 molecular chaperone complex.
  10. TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome.
    Title: TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HTP PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
mitochondrial import receptor subunit TOM34
Names
outer mitochondrial membrane translocase (34kD)
translocase of outer membrane 34 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006809.5 → NP_006800.2  mitochondrial import receptor subunit TOM34

    See identical proteins and their annotated locations for NP_006800.2

    Status: REVIEWED

    Source sequence(s)
    BC001763, BC006573, BC007423, BI560064
    Consensus CDS
    CCDS13340.1
    UniProtKB/Swiss-Prot
    Q15785, Q53GH9, Q6IBN7, Q9NTZ3
    UniProtKB/TrEMBL
    B4DXU3
    Related
    ENSP00000361900.3, ENST00000372813.4
    Conserved Domains (2) summary
    sd00006
    Location:193 → 221
    TPR; TPR repeat [structural motif]
    cl26005
    Location:12 → 294
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    44942130..44960397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528501.2 → XP_011526803.1  mitochondrial import receptor subunit TOM34 isoform X1

    UniProtKB/TrEMBL
    B4DXU3
    Conserved Domains (3) summary
    sd00006
    Location:167 → 195
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:203 → 234
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:166 → 231
    TPR_11; TPR repeat

  2. XM_017027600.3 → XP_016883089.1  mitochondrial import receptor subunit TOM34 isoform X2

    Conserved Domains (3) summary
    smart00028
    Location:88 → 117
    TPR; Tetratricopeptide repeats
    sd00006
    Location:9 → 37
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:10 → 82
    TPR_11; TPR repeat

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    46677999..46696286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322868.1 → XP_054178843.1  mitochondrial import receptor subunit TOM34 isoform X1

  2. XM_054322869.1 → XP_054178844.1  mitochondrial import receptor subunit TOM34 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15785.2 GenPept UniProtKB/Swiss-Prot:Q15785

Gene LinkOut

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