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Zzz3 zinc finger, ZZ domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 108946, updated on 27-Nov-2024

Summary

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Official Symbol
Zzz3provided by MGI
Official Full Name
zinc finger, ZZ domain containing 3provided by MGI
Primary source
MGI:MGI:1920453
See related
Ensembl:ENSMUSG00000039068 AllianceGenome:MGI:1920453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3110065C23Rik; 6430567E01Rik
Summary
Predicted to enable histone reader activity; lysine-acetylated histone binding activity; and methylated histone binding activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Part of ATAC complex. Is expressed in central nervous system and ureter. Orthologous to human ZZZ3 (zinc finger ZZ-type containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.9), CNS E18 (RPKM 7.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zzz3 in Genome Data Viewer
Location:
3 H3; 3 77.16 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152101110..152168463)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152395473..152462826)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm72 Neighboring gene mitoguardin 1 Neighboring gene ubiquitin specific peptidase 33 Neighboring gene predicted gene, 57837 Neighboring gene RIKEN cDNA 3110067G11 gene Neighboring gene STARR-positive B cell enhancer ABC_E4606 Neighboring gene adenylate kinase 5 Neighboring gene expressed sequence AI115009

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
  2. The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes. Nagy Z, et al. Cell Mol Life Sci, 2010 Feb. PMID 19936620, Free PMC Article
  3. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables histone reader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables lysine-acetylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of embryonic development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ZZ-type zinc finger-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080755.2 → NP_001074224.1  ZZ-type zinc finger-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_001074224.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC111139, AC122529
    Consensus CDS
    CCDS38674.1
    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Related
    ENSMUSP00000101706.3, ENSMUST00000106100.9
    Conserved Domains (3) summary
    cd02341
    Location:828 → 878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662 → 710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

  2. NM_001287139.1 → NP_001274068.1  ZZ-type zinc finger-containing protein 3 isoform b

    See identical proteins and their annotated locations for NP_001274068.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AC111139, BC060614, BY305239
    Consensus CDS
    CCDS71338.1
    UniProtKB/TrEMBL
    D3YTT9
    Related
    ENSMUSP00000087428.5, ENSMUST00000089982.11
    Conserved Domains (3) summary
    cd02341
    Location:827 → 877
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:661 → 709
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

  3. NM_001346655.1 → NP_001333584.1  ZZ-type zinc finger-containing protein 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC111139, AK165882
    Consensus CDS
    CCDS84698.1
    UniProtKB/Swiss-Prot
    Q6KAQ7
    Related
    ENSMUSP00000101709.2, ENSMUST00000106103.8
    Conserved Domains (2) summary
    cd02341
    Location:327 → 377
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:161 → 209
    Myb_DNA-binding; Myb-like DNA-binding domain

  4. NM_001355673.1 → NP_001342602.1  ZZ-type zinc finger-containing protein 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC111139, AC122529
    Consensus CDS
    CCDS38674.1
    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Conserved Domains (3) summary
    cd02341
    Location:828 → 878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662 → 710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    152101110..152168463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319423.3 → XP_017174912.1  ZZ-type zinc finger-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Conserved Domains (3) summary
    cd02341
    Location:828 → 878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662 → 710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

  2. XM_006500852.5 → XP_006500915.1  ZZ-type zinc finger-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006500915.1

    UniProtKB/TrEMBL
    D3YTT9
    Conserved Domains (3) summary
    cd02341
    Location:827 → 877
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:661 → 709
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

  3. XM_011239984.4 → XP_011238286.1  ZZ-type zinc finger-containing protein 3 isoform X3

    Conserved Domains (1) summary
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

  4. XM_006500854.5 → XP_006500917.1  ZZ-type zinc finger-containing protein 3 isoform X5

    Conserved Domains (1) summary
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

  5. XM_006500853.5 → XP_006500916.1  ZZ-type zinc finger-containing protein 3 isoform X4

    Conserved Domains (1) summary
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

  6. XM_006500857.5 → XP_006500920.1  ZZ-type zinc finger-containing protein 3 isoform X8

    See identical proteins and their annotated locations for XP_006500920.1

    UniProtKB/Swiss-Prot
    Q6KAQ7
    Conserved Domains (2) summary
    cd02341
    Location:327 → 377
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:161 → 209
    Myb_DNA-binding; Myb-like DNA-binding domain

  7. XM_006500855.5 → XP_006500918.1  ZZ-type zinc finger-containing protein 3 isoform X6

    Conserved Domains (2) summary
    cd02341
    Location:332 → 382
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:166 → 214
    Myb_DNA-binding; Myb-like DNA-binding domain

  8. XM_036162811.1 → XP_036018704.1  ZZ-type zinc finger-containing protein 3 isoform X4

    Conserved Domains (1) summary
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

  9. XM_006500856.5 → XP_006500919.1  ZZ-type zinc finger-containing protein 3 isoform X7

    See identical proteins and their annotated locations for XP_006500919.1

    UniProtKB/Swiss-Prot
    Q6KAQ7
    Related
    ENSMUSP00000143693.2, ENSMUST00000200570.5
    Conserved Domains (2) summary
    cd02341
    Location:331 → 381
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:165 → 213
    Myb_DNA-binding; Myb-like DNA-binding domain

  10. XM_030252353.2 → XP_030108213.1  ZZ-type zinc finger-containing protein 3 isoform X8

    Conserved Domains (2) summary
    cd02341
    Location:327 → 377
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:161 → 209
    Myb_DNA-binding; Myb-like DNA-binding domain

  11. XM_006500848.5 → XP_006500911.1  ZZ-type zinc finger-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006500911.1

    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Related
    ENSMUSP00000101707.2, ENSMUST00000106101.2
    Conserved Domains (3) summary
    cd02341
    Location:828 → 878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662 → 710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

  12. XM_030252350.2 → XP_030108210.1  ZZ-type zinc finger-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Conserved Domains (3) summary
    cd02341
    Location:828 → 878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662 → 710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

  13. XM_030252352.2 → XP_030108212.1  ZZ-type zinc finger-containing protein 3 isoform X6

    Conserved Domains (2) summary
    cd02341
    Location:332 → 382
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:166 → 214
    Myb_DNA-binding; Myb-like DNA-binding domain

  14. XM_006500850.4 → XP_006500913.1  ZZ-type zinc finger-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006500913.1

    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Conserved Domains (3) summary
    cd02341
    Location:828 → 878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662 → 710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343 → 418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

RNA

  1. XR_867209.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198416.2: Suppressed sequence

    Description
    NM_198416.2: This RefSeq was permanently suppressed because currently there is support for the protein but not for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6KAQ7.2 GenPept UniProtKB/Swiss-Prot:Q6KAQ7

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