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FGL2 fibrinogen like 2 [ Homo sapiens (human) ]

Gene ID: 10875, updated on 27-Nov-2024

Summary

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Official Symbol
FGL2provided by HGNC
Official Full Name
fibrinogen like 2provided by HGNC
Primary source
HGNC:HGNC:3696
See related
Ensembl:ENSG00000127951 MIM:605351; AllianceGenome:HGNC:3696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T49; pT49
Summary
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 83.3), appendix (RPKM 61.0) and 22 other tissues See more
Orthologs
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Genomic context

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See FGL2 in Genome Data Viewer
Location:
7q11.23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (77193369..77199819, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (78444483..78450933, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76822686..76829136, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 185, member A pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76750721-76751222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76751223-76751722 Neighboring gene uncharacterized LOC124901678 Neighboring gene ribosomal protein L7a pseudogene 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26203 Neighboring gene coiled-coil domain containing 146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26204 Neighboring gene uncharacterized LOC105375359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18319 Neighboring gene uncharacterized LOC102723791 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:76900911-76901093

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Increased activity of cell membrane-associated prothrombinase, fibrinogen-like protein 2, in peripheral blood mononuclear cells of B-cell lymphoma patients. Rabizadeh E, et al. PLoS One, 2014. PMID 25303152, Free PMC Article
  2. [THE EFFECT OF INFECTIOUS AND AUTOIMMUNE DISEASES ON PROCOAGULANT ACTIVITY OF FIBRINOGEN-LIKE PROTEIN 2 IN THE PERIPHERAL BLOOD]. Cherny I, et al. Harefuah, 2019 Mar. PMID 30916506
  3. Serum soluble fibrinogen-like protein 2 concentration predicts delirium after acute pancreatitis. Xu WB, et al. Brain Behav, 2019 Apr. PMID 30884164, Free PMC Article
  4. The relationship between serum fibrinogen-like protein 2 concentrations and 30-day mortality of patients with traumatic brain injury. Chen TJ, et al. Clin Chim Acta, 2019 Feb. PMID 30503273
  5. The Role of Fibrinogen-Like Protein 2 on Immunosuppression and Malignant Progression in Glioma. Latha K, et al. J Natl Cancer Inst, 2019 Mar 1. PMID 29947810, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD8[+] T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcgammaRIIB.
    Title: CD8(+) T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcγRIIB.
  2. Presence and activity of Fibrinogen like protein 2 in platelets.
    Title: Presence and activity of Fibrinogen like protein 2 in platelets.
  3. A homozygous truncating mutation of FGL2 is associated with immune dysregulation.
    Title: A homozygous truncating mutation of FGL2 is associated with immune dysregulation.
  4. Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis.
    Title: Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis.
  5. Fibrinogen-like protein 2 in gastrointestinal stromal tumour.
    Title: Fibrinogen-like protein 2 in gastrointestinal stromal tumour.
  6. Soluble fibrinogenlike protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.
    Title: Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.
  7. Predictive value of soluble fibrinogen-like protein 2 for survival in traumatic patients with sepsis.
    Title: Predictive value of soluble fibrinogen-like protein 2 for survival in traumatic patients with sepsis.
  8. Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.
    Title: Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.
  9. Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production.
    Title: Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5(n-3 DPA) production.
  10. Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions.
    Title: Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of fibrinogen-like 2 (FGL2) in peptide-treated PBMCs PubMed
Tat tat HIV-1 Tat downregulates the expression of fibrinogen-like 2 (FGL2) in human primary T cells PubMed
Vif vif HIV-1 Vif downregulates the expression of fibrinogen-like 2 (FGL2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of dendritic cell antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of macrophage antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of memory T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of fibrinogen complex TAS
Traceable Author Statement
more info
 PubMed 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
fibroleukin
Names
fibrinogen-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006682.3 → NP_006673.1  fibroleukin precursor

    See identical proteins and their annotated locations for NP_006673.1

    Status: REVIEWED

    Source sequence(s)
    AC007000, BC033820
    Consensus CDS
    CCDS5591.1
    UniProtKB/Swiss-Prot
    Q14314
    UniProtKB/TrEMBL
    A4D1B8, Q53GD2
    Related
    ENSP00000248598.5, ENST00000248598.6
    Conserved Domains (2) summary
    cl00085
    Location:209 → 435
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl27170
    Location:28 → 161
    DUF460; Protein of unknown function (DUF460)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    77193369..77199819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    78444483..78450933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14314.1 GenPept UniProtKB/Swiss-Prot:Q14314

Gene LinkOut

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