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Hipk2r16 Hipk2R16 erythroid cis-regulatory module [ Mus musculus (house mouse) ]

Gene ID: 108511959, updated on 9-Aug-2024

Summary

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Gene symbol
Hipk2r16
Gene description
Hipk2R16 erythroid cis-regulatory module
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr366722
Summary
This genomic element is located in an intron of the Hipk2 (homeodomain interacting protein kinase 2) gene on chromosome 6. It was predicted to be a cis-regulatory module (preCRM) based on the presence of a non-conserved consensus binding motif for the essential erythroid transcription factor GATA1, and on distinctive alignment patterns that yielded a positive regulatory potential score. It was validated as a functional enhancer by reporter assays in transiently transfected human K562 erythroleukemia cells. [provided by RefSeq, Aug 2016]
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Genomic context

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See Hipk2r16 in Genome Data Viewer
Location:
6 B
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (38748217..38748386)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (38771282..38771451)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Clec2l Hedgehog-responsive enhancer Neighboring gene C-type lectin domain family 2, member L Neighboring gene STARR-positive B cell enhancer mm9_chr6:38676623-38676923 Neighboring gene STARR-positive B cell enhancer mm9_chr6:38677325-38677625 Neighboring gene homeodomain interacting protein kinase 2 Neighboring gene RIKEN cDNA 4930502C15 gene Neighboring gene predicted gene, 53285 Neighboring gene thromboxane A synthase 1, platelet Neighboring gene predicted gene, 33767 Neighboring gene predicted gene, 57771

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Experimental validation of predicted mammalian erythroid cis-regulatory modules. Wang H, et al. Genome Res, 2006 Dec. PMID 17038566, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • Hipk2R16 erythroid enhancer
  • Hipk2R16 preCRM
  • regulatory region 366722

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051411.1 

    Range
    101..270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    38748217..38748386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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