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Sox10-mcs5 Sox10 multiple-species conserved sequence 5 [ Mus musculus (house mouse) ]

Gene ID: 107966118, updated on 9-Aug-2024

Summary

Gene symbol
Sox10-mcs5
Gene description
Sox10 multiple-species conserved sequence 5
Gene type
biological region
Feature type(s)
protein_bind
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U2; MCS5; Rr366664
Summary
This region represents a conserved enhancer located approximately 40 kb upstream of the SRY-box 10 (Sox10) gene. This sequence drives expression of a transgene in tissues that express Sox10, including the ganglia, oligodendrocytes, and melanoblasts. Expression in oligodendrocytes is induced by binding by oligodendrocyte lineage transcription factor 2 and negatively regulated by NK6 homeobox 2. [provided by RefSeq, Sep 2016]
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Genomic context

See Sox10-mcs5 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79085639..79086309)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79201439..79202109)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene SRY (sex determining region Y)-box 10 Neighboring gene MCS1C/MCS2 enhancer region 5' of Sox10 Neighboring gene predicted gene 10863 Neighboring gene predicted gene, 53902 Neighboring gene Sox10 multiple-species conserved sequence 4 Neighboring gene Sox10 multiple-species conserved sequence 7 Neighboring gene Sox10 multiple-species conserved sequence 8 Neighboring gene predicted gene, 52189 Neighboring gene STARR-seq mESC enhancer starr_39171 Neighboring gene Sox10 multiple-species conserved sequence 9 Neighboring gene predicted gene, 30527

Genomic regions, transcripts, and products

General gene information

Other Names

  • MCS5 enhancer upstream of Sox10
  • regulatory region 366664

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050691.1 

    Range
    101..771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79085639..79086309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)