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LOC107403166 origin of replication in ribosomal DNA intergenic spacer [ Mus musculus (house mouse) ]

Gene ID: 107403166, updated on 14-Mar-2024

Summary

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Gene symbol
LOC107403166
Gene description
origin of replication in ribosomal DNA intergenic spacer
Gene type
biological region
Feature type(s)
misc_structure
protein_bind
regulatory: DNase_I_hypersensitive_site
rep_origin
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This record represents a region containing multiple origins of DNA replication located within the intergenic spacer of the 45 kb ribosomal DNA repeat. These origins may function ectopically on a plasmid. Members of the origin recognition complex are recruited to this sequence. This region also contains DNase I hypersensitive sites and a sequence element that shows intrinsic bending ability. [provided by RefSeq, Mar 2016]
Annotation information
Note: GeneID:107403166 represents a portion of the ribosomal DNA repeat. Ribosomal DNA repeats are not present in the GRCm38 reference assembly, and therefore, this locus may not be present in the current annotation. [23 Mar 2016]
not in current annotation release
Orthologs
human all
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Genomic context

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Location:
chromosome: 17

Genomic regions, transcripts, and products

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Genome Annotation Status: not in current annotation release
Genomic Sequence:
NG_046816.1 Biological Region

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Site-specific interaction of the murine pre-replicative complex with origin DNA: assembly and disassembly during cell cycle transit and differentiation. Zellner E, et al. Nucleic Acids Res, 2007. PMID 17916579, Free PMC Article
  2. The mouse ribosomal DNA amplification promoting sequence 1 is highly methylated and repeated in the genome. Grozdanov PN, et al. Z Naturforsch C J Biosci, 2002 Sep-Oct. PMID 12440730
  3. Activation of SV40 DNA replication in vivo by amplification-promoting sequences of the mouse ribosomal gene cluster. Staib C, et al. Chromosoma, 1998 Mar. PMID 9567199
  4. Temporal order of replication of mouse ribosomal RNA genes during the cell cycle. Berger C, et al. Chromosoma, 1997 Dec. PMID 9426279
  5. Structural analysis of mouse rDNA: coincidence between nuclease hypersensitive sites, DNA curvature and regulatory elements in the intergenic spacer. Längst G, et al. Nucleic Acids Res, 1997 Feb 1. PMID 9016589, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046816.1 

    Range
    101..5937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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Research Materials