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Slc25a45 solute carrier family 25, member 45 [ Mus musculus (house mouse) ]

Gene ID: 107375, updated on 27-Nov-2024

Summary

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Official Symbol
Slc25a45provided by MGI
Official Full Name
solute carrier family 25, member 45provided by MGI
Primary source
MGI:MGI:2147731
See related
Ensembl:ENSMUSG00000024818 AllianceGenome:MGI:2147731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; and urinary system. Orthologous to human SLC25A45 (solute carrier family 25 member 45). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in duodenum adult (RPKM 85.7), small intestine adult (RPKM 41.3) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Slc25a45 in Genome Data Viewer
Location:
19 A; 19 4.34 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5927828..5935796)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5877801..5885768)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene nuclear paraspeckle assembly transcript 1 (non-protein coding) Neighboring gene STARR-seq mESC enhancer starr_45410 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5844330-5844513 Neighboring gene STARR-seq mESC enhancer starr_45411 Neighboring gene FERM domain containing 8, opposite strand Neighboring gene FERM domain containing 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5878208-5878317 Neighboring gene STARR-positive B cell enhancer ABC_E1522 Neighboring gene tigger transposable element derived 3 Neighboring gene double PHD fingers 2 Neighboring gene STARR-positive B cell enhancer ABC_E7628

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 25 member 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361973.1 → NP_001348902.1  solute carrier family 25 member 45 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC142098
    Consensus CDS
    CCDS29482.1
    UniProtKB/Swiss-Prot
    Q3TC75, Q3UZE9, Q8CFJ7, Q8VBZ7
    Related
    ENSMUSP00000121596.2, ENSMUST00000155697.8
    Conserved Domains (1) summary
    pfam00153
    Location:197 → 288
    Mito_carr; Mitochondrial carrier protein

  2. NM_001361974.1 → NP_001348903.1  solute carrier family 25 member 45 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC142098
    Consensus CDS
    CCDS89319.1
    UniProtKB/TrEMBL
    A0A494BAQ4, D3Z5G2
    Related
    ENSMUSP00000117220.2, ENSMUST00000145200.8
    Conserved Domains (1) summary
    pfam00153
    Location:139 → 230
    Mito_carr; Mitochondrial carrier protein

  3. NM_001425851.1 → NP_001412780.1  solute carrier family 25 member 45 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC142098
    UniProtKB/TrEMBL
    A0A494BAQ4

  4. NM_134154.4 → NP_598915.1  solute carrier family 25 member 45 isoform 1

    See identical proteins and their annotated locations for NP_598915.1

    Status: VALIDATED

    Source sequence(s)
    AC142098
    Consensus CDS
    CCDS29482.1
    UniProtKB/Swiss-Prot
    Q3TC75, Q3UZE9, Q8CFJ7, Q8VBZ7
    Related
    ENSMUSP00000025732.8, ENSMUST00000025732.14
    Conserved Domains (1) summary
    pfam00153
    Location:197 → 288
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5927828..5935796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161393.1 → XP_036017286.1  solute carrier family 25 member 45 isoform X1

    UniProtKB/TrEMBL
    A0A494BAQ4, D3Z5G2
    Conserved Domains (1) summary
    pfam00153
    Location:139 → 230
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFJ7.1 GenPept UniProtKB/Swiss-Prot:Q8CFJ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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