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CCT6B chaperonin containing TCP1 subunit 6B [ Homo sapiens (human) ]

Gene ID: 10693, updated on 27-Nov-2024

Summary

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Official Symbol
CCT6Bprovided by HGNC
Official Full Name
chaperonin containing TCP1 subunit 6Bprovided by HGNC
Primary source
HGNC:HGNC:1621
See related
Ensembl:ENSG00000132141 MIM:610730; AllianceGenome:HGNC:1621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cctz2; CCTZ-2; TSA303; CCT-zeta-2; TCP-1-zeta-2
Summary
This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Biased expression in testis (RPKM 57.4) and thyroid (RPKM 1.2) See more
Orthologs
mouse all
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Genomic context

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See CCT6B in Genome Data Viewer
Location:
17q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (34927861..34961460, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (35874857..35908474, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33254880..33288479, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903987 Neighboring gene uncharacterized LOC105371742 Neighboring gene MPRA-validated peak2814 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:33125526-33126225 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:33145950-33146154 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:33147431-33148040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33153032-33153566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33153567-33154101 Neighboring gene Sharpr-MPRA regulatory region 1211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12046 Neighboring gene Sharpr-MPRA regulatory region 18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8432 Neighboring gene zinc finger protein 830 Neighboring gene DNA ligase 3 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 7 Neighboring gene ring finger and FYVE like domain containing E3 ubiquitin protein ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The genetic landscape of mutations in Burkitt lymphoma. Love C, et al. Nat Genet, 2012 Dec. PMID 23143597, Free PMC Article
  2. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. Ozaki K, et al. Genomics, 1996 Sep 1. PMID 8812458
  3. Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. Kubota H, et al. FEBS Lett, 1997 Jan 27. PMID 9013858
  4. PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates. Stirling PC, et al. J Biol Chem, 2006 Mar 17. PMID 16415341
  5. The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. Gestaut D, et al. Cell, 2019 Apr 18. PMID 30955883, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo
    Title: PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.
  2. Describes the cloning of a very similar protein in mouse.
    Title: Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
T-complex protein 1 subunit zeta-2
Names
chaperonin containing TCP1, subunit 6B (zeta 2)
chaperonin-containing T-complex polypeptide 1, subunit 6B
testis-specific Tcp20
testis-specific protein TSA303

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193529.3 → NP_001180458.1  T-complex protein 1 subunit zeta-2 isoform 2

    See identical proteins and their annotated locations for NP_001180458.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK301773, DB032371
    Consensus CDS
    CCDS54106.1
    UniProtKB/Swiss-Prot
    Q92526
    Related
    ENSP00000398044.3, ENST00000421975.7
    Conserved Domains (2) summary
    cd03342
    Location:23 → 489
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02347
    Location:3 → 493
    chap_CCT_zeta; T-complex protein 1, zeta subunit

  2. NM_001193530.2 → NP_001180459.1  T-complex protein 1 subunit zeta-2 isoform 3

    See identical proteins and their annotated locations for NP_001180459.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AK301773, AK302344, BC027591, DB032371
    Consensus CDS
    CCDS54105.1
    UniProtKB/Swiss-Prot
    Q92526
    Related
    ENSP00000400917.3, ENST00000436961.7
    Conserved Domains (2) summary
    cd03342
    Location:23 → 481
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02347
    Location:3 → 485
    chap_CCT_zeta; T-complex protein 1, zeta subunit

  3. NM_006584.4 → NP_006575.2  T-complex protein 1 subunit zeta-2 isoform 1

    See identical proteins and their annotated locations for NP_006575.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK301773, BC026125, DB032371
    Consensus CDS
    CCDS32617.1
    UniProtKB/Swiss-Prot
    B4DX20, B4DYB0, Q8TC34, Q92526
    Related
    ENSP00000327191.5, ENST00000314144.10
    Conserved Domains (2) summary
    cd03342
    Location:23 → 526
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02347
    Location:3 → 530
    chap_CCT_zeta; T-complex protein 1, zeta subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    34927861..34961460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    35874857..35908474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92526.5 GenPept UniProtKB/Swiss-Prot:Q92526

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