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Dlk2 delta like non-canonical Notch ligand 2 [ Mus musculus (house mouse) ]

Gene ID: 106565, updated on 27-Nov-2024

Summary

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Official Symbol
Dlk2provided by MGI
Official Full Name
delta like non-canonical Notch ligand 2provided by MGI
Primary source
MGI:MGI:2146838
See related
Ensembl:ENSMUSG00000047428 AllianceGenome:MGI:2146838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DLK-2; Egfl9
Summary
Enables identical protein binding activity. Involved in regulation of fat cell differentiation. Acts upstream of or within negative regulation of Notch signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; brain; limb mesenchyme; metanephros; and musculoskeletal system. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 29.8), frontal lobe adult (RPKM 21.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Dlk2 in Genome Data Viewer
Location:
17 C; 17 22.9 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46608342..46614197)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46297256..46303271)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 73 Neighboring gene tight junction associated protein 1 Neighboring gene predicted gene, 41588 Neighboring gene ATP-binding cassette, sub-family C member 10 Neighboring gene STARR-positive B cell enhancer ABC_E1943 Neighboring gene cDNA sequence BC040756 Neighboring gene zinc finger protein 318 Neighboring gene predicted gene 9706

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Delta-like 2 negatively regulates chondrogenic differentiation. Xu W, et al. J Cell Physiol, 2018 Sep. PMID 29057471
  2. Deletion of Dlk2 increases the vulnerability to anxiety-like behaviors and impairs the anxiolytic action of alprazolam. Navarrete F, et al. Psychoneuroendocrinology, 2017 Nov. PMID 28863347
  3. Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis. Garcia-Gallastegi P, et al. Histochem Cell Biol, 2019 Jul. PMID 30888503
  4. Characterization of a proximal Sp1 response element in the mouse Dlk2 gene promoter. Rivero S, et al. BMC Mol Biol, 2011 Dec 20. PMID 22185379, Free PMC Article
  5. Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation. Chen X, et al. Cell Death Dis, 2023 Sep 5. PMID 37669921, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation.
    Title: Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation.
  2. The expression of the Dlk2 protein in the limb bud could be detected at embryonic day 11.5.
    Title: Delta-like 2 negatively regulates chondrogenic differentiation.
  3. The expression pattern of DLK2 indicates that both proteins could play a synergistic role during cell differentiation.
    Title: Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis.
  4. Deletion of Dlk2 increased anxiety and depressive-like behaviors and altered the vulnerability to restraint stress.
    Title: Deletion of Dlk2 increases the vulnerability to anxiety-like behaviors and impairs the anxiolytic action of alprazolam.
  5. KLF4 mediates the transcriptional regulation of Dlk2 in response to IBMX during the early stages of adipogenesis
    Title: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis.
  6. Our results provide the first characterization of Dlk2 transcripts, map the location of the Dlk2 core promoter, and show the role of Sp1 as a key regulator of Dlk2 transcription
    Title: Characterization of a proximal Sp1 response element in the mouse Dlk2 gene promoter.
  7. Data show that DLK1 and DLK2 act as inhibitory non-canonical protein ligands for the NOTCH1 receptor that modulate NOTCH signaling.
    Title: The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities.
  8. Adipogenesis may be modulated by the coordinated expression of Dlk1 and EGFL9/Dlk2.
    Title: The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein delta homolog 2
Names
EGF-like protein 9
EGF-like-domain, multiple 9
delta-like 2 homolog
endothelial cell-specific protein S-1
epidermal growth factor-like protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286013.2 → NP_001272942.1  protein delta homolog 2 precursor

    See identical proteins and their annotated locations for NP_001272942.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT009572
    Consensus CDS
    CCDS37634.2
    UniProtKB/Swiss-Prot
    B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3
    Related
    ENSMUSP00000128897.2, ENSMUST00000166617.8
    Conserved Domains (1) summary
    cd00054
    Location:174 → 210
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  2. NM_001286028.2 → NP_001272957.1  protein delta homolog 2 precursor

    See identical proteins and their annotated locations for NP_001272957.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT009572
    Consensus CDS
    CCDS37634.2
    UniProtKB/Swiss-Prot
    B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3
    Related
    ENSMUSP00000126993.2, ENSMUST00000166280.8
    Conserved Domains (1) summary
    cd00054
    Location:174 → 210
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  3. NM_001414441.1 → NP_001401370.1  protein delta homolog 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT009572
    UniProtKB/Swiss-Prot
    B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3

  4. NM_001414442.1 → NP_001401371.1  protein delta homolog 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT009572
    UniProtKB/Swiss-Prot
    B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3

  5. NM_001414443.1 → NP_001401372.1  protein delta homolog 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT009572
    UniProtKB/Swiss-Prot
    B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3
    Related
    ENSMUSP00000058470.7, ENSMUST00000061722.13

  6. NM_001414444.1 → NP_001401373.1  protein delta homolog 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT009572
    UniProtKB/Swiss-Prot
    B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46608342..46614197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_134120.2: Suppressed sequence

    Description
    NM_134120.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_207666.2: Suppressed sequence

    Description
    NM_207666.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1E3.3 GenPept UniProtKB/Swiss-Prot:Q8K1E3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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