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TGOLN2 trans-golgi network protein 2 [ Homo sapiens (human) ]

Gene ID: 10618, updated on 27-Nov-2024

Summary

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Official Symbol
TGOLN2provided by HGNC
Official Full Name
trans-golgi network protein 2provided by HGNC
Primary source
HGNC:HGNC:15450
See related
Ensembl:ENSG00000152291 MIM:603062; AllianceGenome:HGNC:15450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGN38; TGN46; TGN48; TGN51; TTGN2; hTGN46; hTGN48; hTGN51
Summary
This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in kidney (RPKM 63.9), thyroid (RPKM 61.7) and 25 other tissues See more
Orthologs
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Genomic context

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See TGOLN2 in Genome Data Viewer
Location:
2p11.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85318027..85327989, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85320018..85329980, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85545150..85555112, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transcription factor 7 like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85440681-85441182 Neighboring gene uncharacterized LOC102724579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85442025-85442959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85461879-85462384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85464915-85465420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85465421-85465924 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85482618-85483340 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85483341-85484064 Neighboring gene Sharpr-MPRA regulatory region 427 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85486956-85487677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85489661-85490588 Neighboring gene SNRPE pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11695 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85517073-85517573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85521502-85522173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85533336-85533836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85536759-85537642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85540508-85541008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85561675-85562174 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 2 Neighboring gene retinol saturase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer. Gerashchenko T, et al. Gene, 2024 Aug 20. PMID 38670394
  2. Sorting of secretory proteins at the trans-Golgi network by human TGN46. Lujan P, et al. Elife, 2024 Mar 11. PMID 38466628, Free PMC Article
  3. Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs. Kain R, et al. J Biol Chem, 1998 Jan 9. PMID 9422759
  4. The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2. Nagashima S, et al. Arch Virol, 2014 May. PMID 24221250
  5. VPg-primed RNA synthesis of norovirus RNA-dependent RNA polymerases by using a novel cell-based assay. Subba-Reddy CV, et al. J Virol, 2011 Dec. PMID 21994457, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer.
    Title: Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer.
  2. Sorting of secretory proteins at the trans-Golgi network by human TGN46.
    Title: Sorting of secretory proteins at the trans-Golgi network by human TGN46.
  3. Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.
    Title: Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.
  4. These results indicate that hepatitis E virus (HEV)forms membrane-associated particles in the cytoplasm, and that the released HEV particles with a lipid membrane retain the antigenicity of TGOLN2 on their surface.
    Title: The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.
  5. These analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders.
    Title: Case-control association study of TGOLN2 in attempted suicide.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Case-control association study of TGOLN2 in attempted suicide.
  7. These data have identified different itineraries for the retrograde transport of Shiga toxin and TGN38 and distinct retromer components that regulate the transport of these cargos.
    Title: Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin.
  8. FXIII-A associated with podosomes & other structures adjacent to the plasma membrane, containing TGN46 & GM130 but not protein disulphide isomerase. FXIII-A was present in GM130-positive intracellular vesicles that could mediate its transport.
    Title: Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag co-localizes with Rab9 and TGN38 in endosomes and trans-Golgi compartments PubMed
Vpu vpu HIV-1 Vpu co-localizes with the trans-golgi network protein TGN46 in CD4+ T cells PubMed
vpu Vpu interferes with tetherin trafficking to the cell-surface and causes a relocalization of the cellular tetherin with a TGN marker TGN46 in the TGN PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14722

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in transport vesicle TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
trans-Golgi network integral membrane protein 2
Names
TGN38 homolog
trans-Golgi network glycoprotein 46
trans-Golgi network glycoprotein 48
trans-Golgi network glycoprotein 51
trans-Golgi network protein TGN51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030379.2 RefSeqGene

    Range
    5308..15270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206840.2 → NP_001193769.1  trans-Golgi network integral membrane protein 2 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, A allele) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1. This variant (2, A allele) differs at 1 nt position compared to variant 2, B allele.
    Source sequence(s)
    AA723637, AC093162, AF027516, AL710137, BC008461, BY798185
    UniProtKB/TrEMBL
    A0AAG2UW97
    Conserved Domains (1) summary
    PTZ00121
    Location:55 → 330
    PTZ00121; MAEBL; Provisional

  2. NM_001206841.2 → NP_001193770.1  trans-Golgi network integral membrane protein 2 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, A allele) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a longer and distinct C-terminus, compared to isoform 1. This variant (3, A allele) differs at 1 nt position compared to variant 3, B allele.
    Source sequence(s)
    AA723637, AC093162, AL710137, BC008461, BY798185
    UniProtKB/TrEMBL
    A0AAG2UWR8
    Conserved Domains (1) summary
    PTZ00121
    Location:55 → 330
    PTZ00121; MAEBL; Provisional

  3. NM_001206844.2 → NP_001193773.1  trans-Golgi network integral membrane protein 2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001193773.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks an in-frame segment of the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AA723637, AC093162, BC008461, BX640868
    Consensus CDS
    CCDS56127.1
    UniProtKB/Swiss-Prot
    O43493
    Related
    ENSP00000381312.2, ENST00000398263.6
    Conserved Domains (1) summary
    PLN03237
    Location:64 → 325
    PLN03237; DNA topoisomerase 2; Provisional

  4. NM_001368095.1 → NP_001355024.1  trans-Golgi network integral membrane protein 2 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, B allele) differs at 1 nt position, resulting in a premature stop codon, compared to variant 2, B allele. The encoded isoform (5) is shorter than isoform 2.
    Source sequence(s)
    AC093162
    Consensus CDS
    CCDS92789.1
    UniProtKB/TrEMBL
    A0AAG2UWR8
    Related
    ENSP00000387035.1, ENST00000409015.5

  5. NM_001368096.1 → NP_001355025.1  trans-Golgi network integral membrane protein 2 isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, B allele) differs at 1 nt position compared to variant 3, A allele. The encoded isoform (6) is the same length as isoform 3 but differs in sequence by 1 aa.
    Source sequence(s)
    AC093162
    Consensus CDS
    CCDS56126.1
    UniProtKB/TrEMBL
    A0A5F9UY30, A0AAG2UWR8
    Related
    ENSP00000386443.3, ENST00000409232.7

  6. NM_006464.4 → NP_006455.2  trans-Golgi network integral membrane protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006455.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    AA723637, AC093162, AL710137, BC008461
    Consensus CDS
    CCDS46351.1
    UniProtKB/Swiss-Prot
    B2R686, B8ZZ88, D6W5K3, F8W8W7, F8WBK2, J3KQ45, O15282, O43492, O43493, O43499, O43500, O43501, Q53G68, Q53GV2, Q6MZV1, Q6ZTM7, Q8N6T8, Q92760, Q96QL2
    UniProtKB/TrEMBL
    A0AAG2UY03
    Related
    ENSP00000366603.3, ENST00000377386.8
    Conserved Domains (2) summary
    pfam17818
    Location:306 → 435
    KCT2; Keratinocyte-associated gene product
    NF000535
    Location:40 → 274
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    85318027..85327989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791763.1 Reference GRCh38.p14 PATCHES

    Range
    244268..254227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    85320018..85329980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43493.4 GenPept UniProtKB/Swiss-Prot:O43493

Gene LinkOut

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