TACC2 transforming acidic coiled-coil containing protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TACC2provided by HGNC
Official Full Name: transforming acidic coiled-coil containing protein 2provided by HGNC
Primary source: HGNC:HGNC:11523
See related: Ensembl:ENSG00000138162 MIM:605302; AllianceGenome:HGNC:11523
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AZU-1; ECTACC
Summary: Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in heart (RPKM 17.2), skin (RPKM 13.6) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.13

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (121989163..122254542)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (122885504..123150842)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (123748678..124014057)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals.
Title: A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals.
Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter.
Title: Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter.
Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema.
Title: Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema.
TACC2 protein is expressed mainly in the nucleus of the endometrial cancer cells.
Title: Promoter-level transcriptome in primary lesions of endometrial cancer identified biomarkers associated with lymph node metastasis.
This finding suggests that TACC2 may be a useful tool as a candidate biomarker to predict the recurrence and prognosis of hepatocellular carcinoma.
Title: High expression of TACC2 in hepatocellular carcinoma is associated with poor prognosis.
These results suggest that TACC2 plays an important role in the cell proliferation of breast carcinoma and therefore immunohistochemical TACC2 status is a candidate of worse prognostic factor in breast cancer cases.
Title: TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation.
Differential expression of the transcripts TACC2 connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
Title: Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
Data suggest that TACC2 is highly expressed in prostate cancer cells and contributes to cell cycle progression and cell proliferation in androgen-nonresponsive prostate cancer cells; overexpression of TACC2 leads to recurrence of prostate cancer.
Title: TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer.
Results revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2.
Title: Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.
TACC2 may mediate an oncogenic effect on breast cancer cells.
Title: Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical/prognostic relevance.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G19896 (e-PCR)
- UniSTS:50464

A002B31 (e-PCR)
- UniSTS:50465

SHGC-147599 (e-PCR)
- UniSTS:172842

D8S2279 (e-PCR)
- UniSTS:473907

RH46540 (e-PCR)
- UniSTS:49973

D10S1628 (e-PCR)
- UniSTS:25937

RH41996 (e-PCR)
- UniSTS:58712

SHGC-31995 (e-PCR)
- UniSTS:81501

D10S2403 (e-PCR)
- UniSTS:30050

D10S1318E (e-PCR)
- UniSTS:24968

RH45823 (e-PCR)
- UniSTS:22723

WI-21650 (e-PCR)
- UniSTS:80099

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables nuclear receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cerebral cortex development	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IEA Inferred from Electronic Annotation more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: transforming acidic coiled-coil-containing protein 2

Names: anti zuai-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029948.3 RefSeqGene

Range

5002..270381

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001291876.2 → NP_001278805.2 transforming acidic coiled-coil-containing protein 2 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks several internal exons in the CDS compared to variant 1. The encoded isoform (e) is shorter than isoform a.

Source sequence(s)

AC063960, AL135793, AL731566

Consensus CDS

CCDS76348.1

UniProtKB/TrEMBL

B2RWP4, E7EMZ9

Related

ENSP00000427618.1, ENST00000515603.5

Conserved Domains (2) summary

PHA03247
Location:15 → 468

PHA03247; large tegument protein UL36; Provisional

pfam05010
Location:2620 → 2820

TACC; Transforming acidic coiled-coil-containing protein (TACC)
NM_001291877.2 → NP_001278806.2 transforming acidic coiled-coil-containing protein 2 isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks several internal exons and uses an alternate splice site in the CDS compared to variant 1. The encoded isoform (f) is shorter than isoform a.

Source sequence(s)

AC063960, AL135793, AL731566

Consensus CDS

CCDS76349.1

UniProtKB/TrEMBL

B7ZMJ9, E9PBC6

Related

ENSP00000424467.1, ENST00000515273.5

Conserved Domains (2) summary

PHA03247
Location:15 → 468

PHA03247; large tegument protein UL36; Provisional

pfam05010
Location:2669 → 2869

TACC; Transforming acidic coiled-coil-containing protein (TACC)
NM_001291878.2 → NP_001278807.1 transforming acidic coiled-coil-containing protein 2 isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate structure in the 5' UTR and 5' coding region and lacks an internal exon compared to variant 1. The encoded isoform (g) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AL135793, BC039311, BC141837, R46074

Consensus CDS

CCDS76351.1

UniProtKB/TrEMBL

D6RAA5

Related

ENSP00000422815.1, ENST00000369004.7

Conserved Domains (3) summary

pfam05010
Location:802 → 1002

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:921 → 1001

FadA; Adhesion protein FadA

cl23765
Location:821 → 923

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001291879.2 → NP_001278808.1 transforming acidic coiled-coil-containing protein 2 isoform h

See identical proteins and their annotated locations for NP_001278808.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and coding region and lacks two internal coding exons compared to variant 1. These differences result in the use of a downstream AUG compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC063960, AL135793, BC015736, R46074

Consensus CDS

CCDS76352.1

UniProtKB/TrEMBL

Q4VXL4

Related

ENSP00000357997.1, ENST00000369001.5

Conserved Domains (1) summary

pfam05010
Location:369 → 569

TACC; Transforming acidic coiled-coil-containing protein (TACC)
NM_006997.4 → NP_008928.1 transforming acidic coiled-coil-containing protein 2 isoform d

See identical proteins and their annotated locations for NP_008928.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses a different structure for its 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform d) has a shorter and distinct N-terminus, compared to isoform a.

Source sequence(s)

AF095791, AL135793, BC039311, R46074

Consensus CDS

CCDS7627.1

UniProtKB/Swiss-Prot

O95359

Related

ENSP00000260733.3, ENST00000260733.7

Conserved Domains (2) summary

pfam05010
Location:820 → 1020

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:939 → 1019

FadA; Adhesion protein FadA
NM_206860.3 → NP_996742.1 transforming acidic coiled-coil-containing protein 2 isoform c

See identical proteins and their annotated locations for NP_996742.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses a different structure for its 5' UTR and 5' coding region, and also lacks an internal coding exon compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AL135793, BC039311, R46074

Consensus CDS

CCDS7628.1

UniProtKB/Swiss-Prot

O95359

Related

ENSP00000353763.3, ENST00000360561.7

Conserved Domains (3) summary

pfam05010
Location:790 → 990

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:909 → 989

FadA; Adhesion protein FadA

cl11495
Location:785 → 917

IncFII_repA; IncFII RepA protein family
NM_206861.3 → NP_996743.1 transforming acidic coiled-coil-containing protein 2 isoform b

See identical proteins and their annotated locations for NP_996743.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks three internal in-frame exons compared to variant 1. The resulting protein (isoform b) is shorter compared to isoform a. Isoform b has also been called the 'short' isoform

Source sequence(s)

AF528098, AL135793, AL731566, R46074

Consensus CDS

CCDS7625.1

UniProtKB/Swiss-Prot

O95359

Related

ENSP00000425062.1, ENST00000513429.5

Conserved Domains (2) summary

pfam05010
Location:888 → 1088

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:1007 → 1087

FadA; Adhesion protein FadA
NM_206862.4 → NP_996744.4 transforming acidic coiled-coil-containing protein 2 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Isoform a has also been called the 'long' isoform.

Source sequence(s)

AC063960, AL135793, AL731566

Consensus CDS

CCDS7626.1

UniProtKB/Swiss-Prot

O95359, Q4VXL0, Q4VXL3, Q4VXL6, Q4VXL7, Q5U5T7, Q86WG6, Q86WG7, Q8TCK9, Q9BVQ1, Q9NZ41, Q9NZR5

UniProtKB/TrEMBL

B2RWP4

Related

ENSP00000358001.1, ENST00000369005.6

Conserved Domains (2) summary

pfam05010
Location:2742 → 2942

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl26464
Location:15 → 468

Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

121989163..122254542

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047424457.1 → XP_047280413.1 transforming acidic coiled-coil-containing protein 2 isoform X28
XM_047424465.1 → XP_047280421.1 transforming acidic coiled-coil-containing protein 2 isoform X37
XM_024447756.1 → XP_024303524.1 transforming acidic coiled-coil-containing protein 2 isoform X1

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2805 → 3005

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl25751
Location:2185 → 2572

DUF4045; Domain of unknown function (DUF4045)

cl26464
Location:24 → 488

Atrophin-1; Atrophin-1 family
XM_005269390.1 → XP_005269447.1 transforming acidic coiled-coil-containing protein 2 isoform X6

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2774 → 2974

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:2893 → 2973

FadA; Adhesion protein FadA

pfam13863
Location:2778 → 2879

DUF4200; Domain of unknown function (DUF4200)
XM_017015485.1 → XP_016870974.1 transforming acidic coiled-coil-containing protein 2 isoform X13

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

PTZ00449
Location:2185 → 2550

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03247
Location:24 → 488

PHA03247; large tegument protein UL36; Provisional

COG1196
Location:2756 → 2947

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006717552.1 → XP_006717615.1 transforming acidic coiled-coil-containing protein 2 isoform X21

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2697 → 2897

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:2816 → 2896

FadA; Adhesion protein FadA

cl02488
Location:2736 → 2899

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_005269388.1 → XP_005269445.1 transforming acidic coiled-coil-containing protein 2 isoform X3

See identical proteins and their annotated locations for XP_005269445.1

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2793 → 2993

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:2912 → 2992

FadA; Adhesion protein FadA

pfam13863
Location:2797 → 2898

DUF4200; Domain of unknown function (DUF4200)
XM_005269392.1 → XP_005269449.1 transforming acidic coiled-coil-containing protein 2 isoform X7

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2763 → 2963

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:2882 → 2962

FadA; Adhesion protein FadA

cl02488
Location:2802 → 2965

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_005269396.1 → XP_005269453.1 transforming acidic coiled-coil-containing protein 2 isoform X20

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2716 → 2916

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:2835 → 2915

FadA; Adhesion protein FadA

cl02488
Location:2755 → 2918

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_005269393.1 → XP_005269450.1 transforming acidic coiled-coil-containing protein 2 isoform X9

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2762 → 2962

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:2881 → 2961

FadA; Adhesion protein FadA

pfam13863
Location:2766 → 2867

DUF4200; Domain of unknown function (DUF4200)
XM_017015486.1 → XP_016870975.1 transforming acidic coiled-coil-containing protein 2 isoform X16

UniProtKB/TrEMBL

B2RWP4
XM_006717553.1 → XP_006717616.1 transforming acidic coiled-coil-containing protein 2 isoform X24

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2685 → 2885

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:2804 → 2884

FadA; Adhesion protein FadA

cl02488
Location:2724 → 2887

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_017015484.1 → XP_016870973.1 transforming acidic coiled-coil-containing protein 2 isoform X4

UniProtKB/TrEMBL

B2RWP4
XM_006717548.1 → XP_006717611.1 transforming acidic coiled-coil-containing protein 2 isoform X11

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2758 → 2958

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:2877 → 2957

FadA; Adhesion protein FadA

pfam13863
Location:2762 → 2863

DUF4200; Domain of unknown function (DUF4200)
XM_017015487.1 → XP_016870976.1 transforming acidic coiled-coil-containing protein 2 isoform X17

UniProtKB/TrEMBL

B2RWP4
XM_006717554.1 → XP_006717617.1 transforming acidic coiled-coil-containing protein 2 isoform X25

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2681 → 2881

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:2800 → 2880

FadA; Adhesion protein FadA

cl02488
Location:2720 → 2883

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_024447761.1 → XP_024303529.1 transforming acidic coiled-coil-containing protein 2 isoform X10

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2760 → 2960

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl25751
Location:2140 → 2527

DUF4045; Domain of unknown function (DUF4045)

cl26464
Location:24 → 488

Atrophin-1; Atrophin-1 family
XM_047424449.1 → XP_047280405.1 transforming acidic coiled-coil-containing protein 2 isoform X12
XM_047424453.1 → XP_047280409.1 transforming acidic coiled-coil-containing protein 2 isoform X19
XM_047424455.1 → XP_047280411.1 transforming acidic coiled-coil-containing protein 2 isoform X23
XM_005269399.1 → XP_005269456.1 transforming acidic coiled-coil-containing protein 2 isoform X31

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2640 → 2840

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:2759 → 2839

FadA; Adhesion protein FadA

pfam13863
Location:2644 → 2745

DUF4200; Domain of unknown function (DUF4200)
XM_024447760.1 → XP_024303528.1 transforming acidic coiled-coil-containing protein 2 isoform X8

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (4) summary

pfam05010
Location:2763 → 2963

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl25751
Location:2143 → 2530

DUF4045; Domain of unknown function (DUF4045)

cl26386
Location:1526 → 1987

DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

cl26464
Location:24 → 488

Atrophin-1; Atrophin-1 family
XM_047424458.1 → XP_047280414.1 transforming acidic coiled-coil-containing protein 2 isoform X30
XM_024447762.1 → XP_024303530.1 transforming acidic coiled-coil-containing protein 2 isoform X18

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2718 → 2918

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl25751
Location:2098 → 2485

DUF4045; Domain of unknown function (DUF4045)

cl26464
Location:24 → 488

Atrophin-1; Atrophin-1 family
XM_047424461.1 → XP_047280417.1 transforming acidic coiled-coil-containing protein 2 isoform X34
XM_017015489.1 → XP_016870978.1 transforming acidic coiled-coil-containing protein 2 isoform X29

UniProtKB/TrEMBL

B2RWP4
XM_047424462.1 → XP_047280418.1 transforming acidic coiled-coil-containing protein 2 isoform X35
XM_017015488.1 → XP_016870977.1 transforming acidic coiled-coil-containing protein 2 isoform X26

UniProtKB/TrEMBL

B2RWP4
XM_047424463.1 → XP_047280419.1 transforming acidic coiled-coil-containing protein 2 isoform X36
XM_024447763.1 → XP_024303531.1 transforming acidic coiled-coil-containing protein 2 isoform X38

Conserved Domains (3) summary

pfam05010
Location:996 → 1196

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl25751
Location:376 → 763

DUF4045; Domain of unknown function (DUF4045)

cl26464
Location:24 → 222

Atrophin-1; Atrophin-1 family
XM_024447764.1 → XP_024303532.1 transforming acidic coiled-coil-containing protein 2 isoform X39

Conserved Domains (2) summary

pfam05010
Location:951 → 1151

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl25751
Location:331 → 718

DUF4045; Domain of unknown function (DUF4045)
XM_011539130.1 → XP_011537432.1 transforming acidic coiled-coil-containing protein 2 isoform X40

Conserved Domains (3) summary

pfam05010
Location:908 → 1108

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:1027 → 1107

FadA; Adhesion protein FadA

cl23765
Location:927 → 1029

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_024447758.1 → XP_024303526.1 transforming acidic coiled-coil-containing protein 2 isoform X2

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2804 → 3004

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl25751
Location:2184 → 2571

DUF4045; Domain of unknown function (DUF4045)

cl26464
Location:23 → 487

Atrophin-1; Atrophin-1 family
XM_024447759.1 → XP_024303527.1 transforming acidic coiled-coil-containing protein 2 isoform X5

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2785 → 2985

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl25751
Location:2165 → 2552

DUF4045; Domain of unknown function (DUF4045)

cl26464
Location:15 → 468

Atrophin-1; Atrophin-1 family
XM_047424451.1 → XP_047280407.1 transforming acidic coiled-coil-containing protein 2 isoform X15
XM_024447757.2 → XP_024303525.1 transforming acidic coiled-coil-containing protein 2 isoform X1

UniProtKB/TrEMBL

B2RWP4

Conserved Domains (3) summary

pfam05010
Location:2805 → 3005

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl25751
Location:2185 → 2572

DUF4045; Domain of unknown function (DUF4045)

cl26464
Location:24 → 488

Atrophin-1; Atrophin-1 family
XM_047424448.1 → XP_047280404.1 transforming acidic coiled-coil-containing protein 2 isoform X5
XM_047424456.1 → XP_047280412.1 transforming acidic coiled-coil-containing protein 2 isoform X27
XM_047424452.1 → XP_047280408.1 transforming acidic coiled-coil-containing protein 2 isoform X15
XM_047424454.1 → XP_047280410.1 transforming acidic coiled-coil-containing protein 2 isoform X22
XM_047424460.1 → XP_047280416.1 transforming acidic coiled-coil-containing protein 2 isoform X33

UniProtKB/TrEMBL

E7EMZ9
XM_047424450.1 → XP_047280406.1 transforming acidic coiled-coil-containing protein 2 isoform X14
XM_047424459.1 → XP_047280415.1 transforming acidic coiled-coil-containing protein 2 isoform X32
XM_047424464.1 → XP_047280420.1 transforming acidic coiled-coil-containing protein 2 isoform X37
XM_047424466.1 → XP_047280422.1 transforming acidic coiled-coil-containing protein 2 isoform X43
XM_024447765.2 → XP_024303533.1 transforming acidic coiled-coil-containing protein 2 isoform X41

Conserved Domains (2) summary

pfam05010
Location:863 → 1063

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl25751
Location:243 → 630

DUF4045; Domain of unknown function (DUF4045)
XM_011539132.3 → XP_011537434.1 transforming acidic coiled-coil-containing protein 2 isoform X42

UniProtKB/TrEMBL

Q4VXL8

Related

ENSP00000357995.1, ENST00000368999.5

Conserved Domains (3) summary

pfam05010
Location:832 → 1032

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:951 → 1031

FadA; Adhesion protein FadA

cl23765
Location:851 → 953

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

122885504..123150842

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054364531.1 → XP_054220506.1 transforming acidic coiled-coil-containing protein 2 isoform X28
XM_054364541.1 → XP_054220516.1 transforming acidic coiled-coil-containing protein 2 isoform X37
XM_054364510.1 → XP_054220485.1 transforming acidic coiled-coil-containing protein 2 isoform X8
XM_054364501.1 → XP_054220476.1 transforming acidic coiled-coil-containing protein 2 isoform X1
XM_054364505.1 → XP_054220480.1 transforming acidic coiled-coil-containing protein 2 isoform X4
XM_054364521.1 → XP_054220496.1 transforming acidic coiled-coil-containing protein 2 isoform X18
XM_054364503.1 → XP_054220478.1 transforming acidic coiled-coil-containing protein 2 isoform X2
XM_054364512.1 → XP_054220487.1 transforming acidic coiled-coil-containing protein 2 isoform X10
XM_054364507.1 → XP_054220482.1 transforming acidic coiled-coil-containing protein 2 isoform X5
XM_054364517.1 → XP_054220492.1 transforming acidic coiled-coil-containing protein 2 isoform X15
XM_054364508.1 → XP_054220483.1 transforming acidic coiled-coil-containing protein 2 isoform X6
XM_054364515.1 → XP_054220490.1 transforming acidic coiled-coil-containing protein 2 isoform X13
XM_054364504.1 → XP_054220479.1 transforming acidic coiled-coil-containing protein 2 isoform X3
XM_054364509.1 → XP_054220484.1 transforming acidic coiled-coil-containing protein 2 isoform X7
XM_054364513.1 → XP_054220488.1 transforming acidic coiled-coil-containing protein 2 isoform X11
XM_054364520.1 → XP_054220495.1 transforming acidic coiled-coil-containing protein 2 isoform X17
XM_054364514.1 → XP_054220489.1 transforming acidic coiled-coil-containing protein 2 isoform X12
XM_054364529.1 → XP_054220504.1 transforming acidic coiled-coil-containing protein 2 isoform X26
XM_054364524.1 → XP_054220499.1 transforming acidic coiled-coil-containing protein 2 isoform X21
XM_054364523.1 → XP_054220498.1 transforming acidic coiled-coil-containing protein 2 isoform X20
XM_054364511.1 → XP_054220486.1 transforming acidic coiled-coil-containing protein 2 isoform X9
XM_054364519.1 → XP_054220494.1 transforming acidic coiled-coil-containing protein 2 isoform X16
XM_054364528.1 → XP_054220503.1 transforming acidic coiled-coil-containing protein 2 isoform X25
XM_054364537.1 → XP_054220512.1 transforming acidic coiled-coil-containing protein 2 isoform X34
XM_054364539.1 → XP_054220514.1 transforming acidic coiled-coil-containing protein 2 isoform X36
XM_054364522.1 → XP_054220497.1 transforming acidic coiled-coil-containing protein 2 isoform X19
XM_054364526.1 → XP_054220501.1 transforming acidic coiled-coil-containing protein 2 isoform X23
XM_054364532.1 → XP_054220507.1 transforming acidic coiled-coil-containing protein 2 isoform X29
XM_054364533.1 → XP_054220508.1 transforming acidic coiled-coil-containing protein 2 isoform X30
XM_054364527.1 → XP_054220502.1 transforming acidic coiled-coil-containing protein 2 isoform X24
XM_054364534.1 → XP_054220509.1 transforming acidic coiled-coil-containing protein 2 isoform X31
XM_054364538.1 → XP_054220513.1 transforming acidic coiled-coil-containing protein 2 isoform X35
XM_054364542.1 → XP_054220517.1 transforming acidic coiled-coil-containing protein 2 isoform X38
XM_054364543.1 → XP_054220518.1 transforming acidic coiled-coil-containing protein 2 isoform X39
XM_054364544.1 → XP_054220519.1 transforming acidic coiled-coil-containing protein 2 isoform X40
XM_054364502.1 → XP_054220477.1 transforming acidic coiled-coil-containing protein 2 isoform X1
XM_054364516.1 → XP_054220491.1 transforming acidic coiled-coil-containing protein 2 isoform X14
XM_054364506.1 → XP_054220481.1 transforming acidic coiled-coil-containing protein 2 isoform X5
XM_054364518.1 → XP_054220493.1 transforming acidic coiled-coil-containing protein 2 isoform X15
XM_054364525.1 → XP_054220500.1 transforming acidic coiled-coil-containing protein 2 isoform X22
XM_054364535.1 → XP_054220510.1 transforming acidic coiled-coil-containing protein 2 isoform X32
XM_054364530.1 → XP_054220505.1 transforming acidic coiled-coil-containing protein 2 isoform X27
XM_054364536.1 → XP_054220511.1 transforming acidic coiled-coil-containing protein 2 isoform X33
XM_054364540.1 → XP_054220515.1 transforming acidic coiled-coil-containing protein 2 isoform X37
XM_054364547.1 → XP_054220522.1 transforming acidic coiled-coil-containing protein 2 isoform X43
XM_054364545.1 → XP_054220520.1 transforming acidic coiled-coil-containing protein 2 isoform X43
XM_054364546.1 → XP_054220521.1 transforming acidic coiled-coil-containing protein 2 isoform X43