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MIR9-1HG MIR9-1 host gene [ Homo sapiens (human) ]

Gene ID: 10485, updated on 4-Jan-2025

Summary

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Official Symbol
MIR9-1HGprovided by HGNC
Official Full Name
MIR9-1 host geneprovided by HGNC
Primary source
HGNC:HGNC:30780
See related
Ensembl:ENSG00000125462 MIM:618747; AllianceGenome:HGNC:30780
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CROC4; C1orf61
Summary
Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward brain (RPKM 43.3) See more
Orthologs
all
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Genomic context

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See MIR9-1HG in Genome Data Viewer
Location:
1q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156404252..156429548, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155542856..155568152, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156374044..156399340, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1859 Neighboring gene TSSK6 activating cochaperone Neighboring gene Sharpr-MPRA regulatory region 198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156362688-156363193 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9068 Neighboring gene Rh family B glycoprotein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156369951-156370626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156371301-156371974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156382372-156382872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156390239-156390770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156391951-156392452 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:156409392-156409986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156409987-156410580 Neighboring gene microRNA 9-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156418512-156419012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1861 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156426495-156427452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156427509-156428010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156428011-156428510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156431759-156432710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156432711-156433660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156445026-156445638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1864 Neighboring gene myocyte enhancer factor 2D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156466171-156466671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156471045-156471824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1868 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156474933-156475335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1870 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156483472-156483678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1430 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:156495835-156496406 Neighboring gene small nucleolar RNA U13 Neighboring gene IQ motif containing GTPase activating protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. C1orf61 promotes hepatocellular carcinoma metastasis and increases the therapeutic response to sorafenib. Yu Y, et al. Biochim Biophys Acta Mol Cell Res, 2021 Jul. PMID 33915231
  2. C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis. Hu HM, et al. FASEB J, 2013 Jan. PMID 23012322
  3. Eight genes are highly associated with BMD variation in postmenopausal Caucasian women. Reppe S, et al. Bone, 2010 Mar. PMID 19922823
  4. CROC-4: a novel brain specific transcriptional activator of c-fos expressed from proliferation through to maturation of multiple neuronal cell types. Jeffrey PL, et al. Mol Cell Neurosci, 2000 Sep. PMID 10995546
  5. LncRNA CACNA1G-AS1 facilitates hepatocellular carcinoma progression through the miR-2392/C1orf61 pathway. Yang J, et al. J Cell Physiol, 2019 Aug. PMID 30908634

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C1orf61 promotes hepatocellular carcinoma metastasis and increases the therapeutic response to sorafenib.
    Title: C1orf61 promotes hepatocellular carcinoma metastasis and increases the therapeutic response to sorafenib.
  2. CACNA1G-AS1 promotes hepatocellular carcinoma progression through regulating the miR-2392/C1orf61 pathway.
    Title: LncRNA CACNA1G-AS1 facilitates hepatocellular carcinoma progression through the miR-2392/C1orf61 pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • contingent replication of cDNA 4
  • protein CROC-4
  • transcriptional activator of the c-fos promoter

Clone Names

  • FLJ38303

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_135260.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI264870, BI667681, U49857
    Related
    ENST00000758279.1

  2. NR_135261.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI264870, AL139130, BC010558, BG716287
    Related
    ENST00000703052.2

  3. NR_135262.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI264870, BC010558, BG716287, BI597719
    Related
    ENST00000758275.1

  4. NR_135263.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI264870, BC010558, BG716287, BI668594
    Related
    ENST00000310027.11

  5. NR_135264.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI264870, BC010558, HY158402, U49857
    Related
    ENST00000357975.6

  6. NR_135265.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI264870, AL139130, DB534652, HY121703
    Related
    ENST00000465270.7

  7. NR_135266.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI264870, AL139130, DB534652, HY137784

  8. NR_135267.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI264870, AL139130, DB534652, HY152089
    Related
    ENST00000497822.7

  9. NR_135268.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI264870, AL139130, BI752228, DB534652, HY152089
    Related
    ENST00000758336.1

  10. NR_168070.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139130
    Related
    ENST00000368243.8

  11. NR_168071.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139130
    Related
    ENST00000703058.2

  12. NR_168072.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139130
    Related
    ENST00000701195.2

  13. NR_168073.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139130
    Related
    ENST00000486517.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156404252..156429548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791758.1 Reference GRCh38.p14 PATCHES

    Range
    4968..15892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007069446.1 RNA Sequence

  2. XR_007069444.1 RNA Sequence

  3. XR_007069447.1 RNA Sequence

  4. XR_007069445.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155542856..155568152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001320453.1: Suppressed sequence

    Description
    NM_001320453.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  2. NM_001320454.2: Suppressed sequence

    Description
    NM_001320454.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  3. NM_001320455.2: Suppressed sequence

    Description
    NM_001320455.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  4. NM_006365.3: Suppressed sequence

    Description
    NM_006365.3: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13536.1 GenPept UniProtKB/Swiss-Prot:Q13536

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