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ZER1 zyg-11 related cell cycle regulator [ Homo sapiens (human) ]

Gene ID: 10444, updated on 27-Nov-2024

Summary

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Official Symbol
ZER1provided by HGNC
Official Full Name
zyg-11 related cell cycle regulatorprovided by HGNC
Primary source
HGNC:HGNC:30960
See related
Ensembl:ENSG00000160445 MIM:617764; AllianceGenome:HGNC:30960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZYG; C9orf60; ZYG11BL
Summary
This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in brain (RPKM 20.9), testis (RPKM 20.5) and 25 other tissues See more
Orthologs
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Genomic context

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See ZER1 in Genome Data Viewer
Location:
9q34.11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128729786..128772486, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140934550..140977266, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131492065..131534765, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131475223-131475724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131475725-131476224 Neighboring gene RNA, 7SL, cytoplasmic 560, pseudogene Neighboring gene protein kinase N3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131491015-131491846 Neighboring gene ZDHHC12 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131491847-131492678 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:131494472-131494972 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:131494973-131495473 Neighboring gene zinc finger DHHC-type palmitoyltransferase 12 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124902282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20351 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131534571-131535297 Neighboring gene CRISPRi-validated cis-regulatory element chr9.3033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20352 Neighboring gene TBC1 domain family member 13 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:131574071-131574244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20353 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131581177-131581742 Neighboring gene KYAT1-SPOUT1 readthrough Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene endonuclease G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Meiotic human sperm cells express a leucine-rich homologue of Caenorhabditis elegans early embryogenesis gene, Zyg-11. Féral C, et al. Mol Hum Reprod, 2001 Dec. PMID 11719588, Free PMC Article
  2. CRL2(ZER1/ZYG11B) recognizes small N-terminal residues for degradation. Li Y, et al. Nat Commun, 2022 Dec 10. PMID 36496439, Free PMC Article
  3. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Timms RT, et al. Science, 2019 Jul 5. PMID 31273098, Free PMC Article
  4. ZER1 Contributes to the Carcinogenic Activity of High-Risk HPV E7 Proteins. Nouel J, et al. mBio, 2022 Dec 20. PMID 36346242, Free PMC Article
  5. Molecular basis for recognition of Gly/N-degrons by CRL2(ZYG11B) and CRL2(ZER1). Yan X, et al. Mol Cell, 2021 Aug 19. PMID 34214466

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular basis for recognition of Gly/N-degrons by CRL2(ZYG11B) and CRL2(ZER1).
    Title: Molecular basis for recognition of Gly/N-degrons by CRL2(ZYG11B) and CRL2(ZER1).
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants associated with disordered eating.
EBI GWAS Catalog
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • RP11-545E17.4

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein zer-1 homolog
Names
ZYG homolog
zer-1 homolog
zyg-11 homolog B-like protein
zyg11b-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375954.1 → NP_001362883.1  protein zer-1 homolog isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Consensus CDS
    CCDS6910.1
    UniProtKB/Swiss-Prot
    O00156, Q5T272, Q5T273, Q7Z7L7
    UniProtKB/TrEMBL
    B2RC26
    Conserved Domains (3) summary
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  2. NM_001375955.1 → NP_001362884.1  protein zer-1 homolog isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Consensus CDS
    CCDS6910.1
    UniProtKB/Swiss-Prot
    O00156, Q5T272, Q5T273, Q7Z7L7
    UniProtKB/TrEMBL
    B2RC26
    Conserved Domains (3) summary
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  3. NM_001375956.1 → NP_001362885.1  protein zer-1 homolog isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Consensus CDS
    CCDS6910.1
    UniProtKB/Swiss-Prot
    O00156, Q5T272, Q5T273, Q7Z7L7
    UniProtKB/TrEMBL
    B2RC26
    Conserved Domains (3) summary
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  4. NM_001375957.1 → NP_001362886.1  protein zer-1 homolog isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL441992
    UniProtKB/TrEMBL
    B2RC26
    Conserved Domains (3) summary
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:560 → 598
    ARM; armadillo repeat [structural motif]

  5. NM_001375958.1 → NP_001362887.1  protein zer-1 homolog isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL441992
    UniProtKB/TrEMBL
    B2RC26
    Conserved Domains (3) summary
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:560 → 598
    ARM; armadillo repeat [structural motif]

  6. NM_001375959.1 → NP_001362888.1  protein zer-1 homolog isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL441992
    UniProtKB/TrEMBL
    B2RC26
    Conserved Domains (2) summary
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]

  7. NM_006336.4 → NP_006327.2  protein zer-1 homolog isoform 1

    See identical proteins and their annotated locations for NP_006327.2

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Consensus CDS
    CCDS6910.1
    UniProtKB/Swiss-Prot
    O00156, Q5T272, Q5T273, Q7Z7L7
    UniProtKB/TrEMBL
    B2RC26
    Related
    ENSP00000291900.2, ENST00000291900.7
    Conserved Domains (3) summary
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    128729786..128772486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014188.2 → XP_016869677.1  protein zer-1 homolog isoform X1

    UniProtKB/TrEMBL
    B2RC26
    Conserved Domains (3) summary
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:560 → 598
    ARM; armadillo repeat [structural motif]

  2. XM_017014187.3 → XP_016869676.1  protein zer-1 homolog isoform X1

    UniProtKB/TrEMBL
    B2RC26
    Conserved Domains (3) summary
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:560 → 598
    ARM; armadillo repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    140934550..140977266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361708.1 → XP_054217683.1  protein zer-1 homolog isoform X1

  2. XM_054361707.1 → XP_054217682.1  protein zer-1 homolog isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z7L7.1 GenPept UniProtKB/Swiss-Prot:Q7Z7L7

Gene LinkOut

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