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Sbk1 SH3-binding kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 104175, updated on 27-Nov-2024

Summary

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Official Symbol
Sbk1provided by MGI
Official Full Name
SH3-binding kinase 1provided by MGI
Primary source
MGI:MGI:2135937
See related
Ensembl:ENSMUSG00000042978 AllianceGenome:MGI:2135937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sbk
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SBK1 (SH3 domain binding kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 125.5), CNS E14 (RPKM 100.4) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Sbk1 in Genome Data Viewer
Location:
7 F3; 7 69.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125847524..125894188)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126248397..126295016)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20132 Neighboring gene STARR-seq mESC enhancer starr_20133 Neighboring gene RIKEN cDNA 1700123J17 gene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20134 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133373927-133374110 Neighboring gene STARR-seq mESC enhancer starr_20135 Neighboring gene STARR-seq mESC enhancer starr_20136 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133415262-133415415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133428849-133429094 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20139 Neighboring gene predicted gene, 30928

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential regulation of hepatic SH3 domain binding kinase 1 (SBK1) expression in mouse and goldfish. Hang M, et al. Gen Comp Endocrinol, 2023 Dec 1. PMID 37652166
  2. Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway. Ahuja P, et al. Hepatology, 2023 Jan 1. PMID 35363898
  3. Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain. Nara K, et al. Eur J Biochem, 2001 May. PMID 11322885
  4. The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Schilling K, et al. Cerebellum, 2009 Dec. PMID 19554387
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential regulation of hepatic SH3 domain binding kinase 1 (SBK1) expression in mouse and goldfish.
    Title: Differential regulation of hepatic SH3 domain binding kinase 1 (SBK1) expression in mouse and goldfish.
  2. Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway.
    Title: Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase SBK1
Names
SH3 domain-binding kinase 1
NP_001347740.1
NP_001390491.1
NP_663562.1
XP_036008449.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360811.2 → NP_001347740.1  serine/threonine-protein kinase SBK1

    Status: VALIDATED

    Source sequence(s)
    AC135809
    Consensus CDS
    CCDS21824.1
    UniProtKB/Swiss-Prot
    Q8QZX0
    UniProtKB/TrEMBL
    A0A0B6VRD5
    Related
    ENSMUSP00000159131.2, ENSMUST00000239081.2
    Conserved Domains (1) summary
    cd13987
    Location:59 → 317
    STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1

  2. NM_001403562.1 → NP_001390491.1  serine/threonine-protein kinase SBK1

    Status: VALIDATED

    Source sequence(s)
    AC135809
    UniProtKB/Swiss-Prot
    Q8QZX0

  3. NM_145587.4 → NP_663562.1  serine/threonine-protein kinase SBK1

    See identical proteins and their annotated locations for NP_663562.1

    Status: VALIDATED

    Source sequence(s)
    AC135809
    Consensus CDS
    CCDS21824.1
    UniProtKB/Swiss-Prot
    Q8QZX0
    UniProtKB/TrEMBL
    A0A0B6VRD5
    Related
    ENSMUSP00000060907.10, ENSMUST00000056028.11
    Conserved Domains (1) summary
    cd13987
    Location:59 → 317
    STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    125847524..125894188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152556.1 → XP_036008449.1  serine/threonine-protein kinase SBK1 isoform X1

    UniProtKB/TrEMBL
    A0A0B6VRD5
    Conserved Domains (1) summary
    cd13987
    Location:67 → 325
    STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QZX0.1 GenPept UniProtKB/Swiss-Prot:Q8QZX0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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