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map4k4 mitogen-activated protein kinase kinase kinase kinase 4 [ Danio rerio (zebrafish) ]

Gene ID: 103908625, updated on 9-Dec-2024

Summary

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Official Symbol
map4k4provided by ZNC
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6722
See related
Ensembl:ENSDARG00000098670 AllianceGenome:ZFIN:ZDB-GENE-030131-6722
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa03e11; wu:fa03e11; si:zfos-433a6.1
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in MAPK cascade; neuron projection morphogenesis; and regulation of MAPK cascade. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See map4k4 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (22095..38385, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (18407..33995, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene ribosomal RNA processing protein 1 homolog A Neighboring gene interleukin-1 receptor type 2 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene interleukin 10 receptor, beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish. Patterson V, et al. Sci Adv, 2023 Apr 28. PMID 37126546, Free PMC Article
  2. Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. Köppen M, et al. Development, 2006 Jul. PMID 16794032
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish.
    Title: Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase kinase 4
Names
msn2
XP_021334466.1
XP_021334469.1
XP_068079619.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    22095..38385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478794.2 → XP_021334469.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QB07
    Conserved Domains (2) summary
    smart00036
    Location:612 → 910
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1 → 209
    PKc_like; Protein Kinases, catalytic domain

  2. XM_068223518.1 → XP_068079619.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QFN8

  3. XM_021478791.2 → XP_021334466.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QFN8
    Related
    ENSDARP00000130351.1, ENSDART00000171335.2
    Conserved Domains (2) summary
    smart00036
    Location:688 → 986
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1 → 209
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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