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Apela apelin receptor early endogenous ligand [ Rattus norvegicus (Norway rat) ]

Gene ID: 103693925, updated on 27-Nov-2024

Summary

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Symbol
Apelaprovided by RGD
Full Name
apelin receptor early endogenous ligandprovided by RGD
Primary source
RGD:9299863
See related
EnsemblRapid:ENSRNOG00000067022 AllianceGenome:RGD:9299863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ELA; Tdl
Summary
Enables apelin receptor binding activity. Involved in apelin receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of heart contraction. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 176.5) and Brain (RPKM 56.6) See more
Orthologs
human mouse all
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Genomic context

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See Apela in Genome Data Viewer
Location:
16p13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (29460855..29469962)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (24694356..24703466)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (26582103..26583828)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B, pseudogene 7 Neighboring gene glycine cleavage system protein H, pseudogene 1 Neighboring gene tripartite motif-containing 60, pseudogene 1 Neighboring gene tripartite motif containing 60

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Vascular Functional Effect Mechanisms of Elabela in Rat Thoracic Aorta. Sahinturk S, et al. Ann Vasc Surg, 2022 Aug. PMID 35472496
  2. Elabela prevents angiotensin II-induced apoptosis and inflammation in rat aortic adventitial fibroblasts via the activation of FGF21-ACE2 signaling. Song JJ, et al. J Mol Histol, 2021 Oct. PMID 34453661, Free PMC Article
  3. Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart. Perjés Á, et al. Basic Res Cardiol, 2016 Jan. PMID 26611206
  4. ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats. Xi Y, et al. Med Sci Sports Exerc, 2023 Jul 1. PMID 36878020

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats.
    Title: ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats.
  2. Vascular Functional Effect Mechanisms of Elabela in Rat Thoracic Aorta.
    Title: Vascular Functional Effect Mechanisms of Elabela in Rat Thoracic Aorta.
  3. Elabela prevents angiotensin II-induced apoptosis and inflammation in rat aortic adventitial fibroblasts via the activation of FGF21-ACE2 signaling.
    Title: Elabela prevents angiotensin II-induced apoptosis and inflammation in rat aortic adventitial fibroblasts via the activation of FGF21-ACE2 signaling.
  4. conclude that apela is present in the adult heart, is upregulated in post-infarction cardiac remodeling, and increases cardiac contractility in an ERK1/2-dependent manner
    Title: Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables apelin receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables apelin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables hormone activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adult heart development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in apelin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apelin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in coronary vasculature development ISO
Inferred from Sequence Orthology
more info
  
involved_in coronary vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic heart tube development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mesoderm migration involved in gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in placenta blood vessel development ISO
Inferred from Sequence Orthology
more info
  
involved_in placenta blood vessel development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of trophoblast cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in vasculogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
apelin receptor early endogenous ligand
Names
Protein Elabela
Protein Toddler

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399424.1 → NP_001386353.1  apelin receptor early endogenous ligand precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    P0DP76
    Related
    ENSRNOP00000082744.1, ENSRNOT00000107155.2
    Conserved Domains (1) summary
    cd20244
    Location:2 → 54
    Toddler; Apelin receptor early endogenous ligand, also called Toddler

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    29460855..29469962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DP76.1 GenPept UniProtKB/Swiss-Prot:P0DP76

Gene LinkOut

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