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Mast4 microtubule associated serine/threonine kinase family member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 103690045, updated on 27-Nov-2024

Summary

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Symbol
Mast4provided by RGD
Full Name
microtubule associated serine/threonine kinase family member 4provided by RGD
Primary source
RGD:1310139
See related
EnsemblRapid:ENSRNOG00000027002 AllianceGenome:RGD:1310139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310139
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization and intracellular signal transduction. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 142.0), Heart (RPKM 85.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mast4 in Genome Data Viewer
Location:
2q13
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (35627190..36219090, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (33893241..34483682, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (32857576..33451802, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349935 Neighboring gene uncharacterized LOC120101075 Neighboring gene CD180 molecule Neighboring gene small nucleolar RNA SNORA15 Neighboring gene uncharacterized LOC120101078 Neighboring gene uncharacterized LOC134485589 Neighboring gene uncharacterized LOC134485830 Neighboring gene uncharacterized LOC120101077 Neighboring gene uncharacterized LOC120100556 Neighboring gene splicing regulatory glutamic acid and lysine rich protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of the MAST family of serine/threonine kinases. Garland P, et al. Brain Res, 2008 Feb 21. PMID 18206861
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
microtubule-associated serine/threonine-protein kinase 4
NP_001408202.1
XP_008758926.1
XP_008758927.1
XP_063137175.1
XP_063137176.1
XP_063137177.1
XP_063137178.1
XP_063137179.1
XP_063137180.1
XP_063137181.1
XP_063137183.1
XP_063137184.1
XP_063137185.1
XP_063137186.1
XP_063137187.1
XP_063137188.1
XP_063137189.1
XP_063137190.1
XP_063137191.1
XP_063137192.1
XP_063137193.1
XP_063137194.1
XP_063137195.1
XP_063137196.1
XP_063137197.1
XP_063137198.1
XP_063137199.1
XP_063137200.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421273.1 → NP_001408202.1  microtubule-associated serine/threonine-protein kinase 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6AUJ4
    Related
    ENSRNOP00000097115.1, ENSRNOT00000117686.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    35627190..36219090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281113.1 → XP_063137183.1  microtubule-associated serine/threonine-protein kinase 4 isoform X8

  2. XM_063281110.1 → XP_063137180.1  microtubule-associated serine/threonine-protein kinase 4 isoform X6

    Related
    ENSRNOP00000104460.1, ENSRNOT00000155998.1

  3. XM_063281115.1 → XP_063137185.1  microtubule-associated serine/threonine-protein kinase 4 isoform X10

  4. XM_063281105.1 → XP_063137175.1  microtubule-associated serine/threonine-protein kinase 4 isoform X1

  5. XM_063281109.1 → XP_063137179.1  microtubule-associated serine/threonine-protein kinase 4 isoform X5

  6. XM_063281106.1 → XP_063137176.1  microtubule-associated serine/threonine-protein kinase 4 isoform X2

  7. XM_063281108.1 → XP_063137178.1  microtubule-associated serine/threonine-protein kinase 4 isoform X4

    Related
    ENSRNOP00000106047.1, ENSRNOT00000140742.1

  8. XM_063281114.1 → XP_063137184.1  microtubule-associated serine/threonine-protein kinase 4 isoform X9

    Related
    ENSRNOP00000086736.2, ENSRNOT00000117830.2

  9. XM_063281107.1 → XP_063137177.1  microtubule-associated serine/threonine-protein kinase 4 isoform X3

    Related
    ENSRNOP00000111002.1, ENSRNOT00000131896.1

  10. XM_063281111.1 → XP_063137181.1  microtubule-associated serine/threonine-protein kinase 4 isoform X7

  11. XM_063281117.1 → XP_063137187.1  microtubule-associated serine/threonine-protein kinase 4 isoform X12

  12. XM_063281118.1 → XP_063137188.1  microtubule-associated serine/threonine-protein kinase 4 isoform X12

  13. XM_063281122.1 → XP_063137192.1  microtubule-associated serine/threonine-protein kinase 4 isoform X16

  14. XM_063281124.1 → XP_063137194.1  microtubule-associated serine/threonine-protein kinase 4 isoform X19

  15. XM_063281120.1 → XP_063137190.1  microtubule-associated serine/threonine-protein kinase 4 isoform X14

    UniProtKB/TrEMBL
    A0A8I6A2A1
    Related
    ENSRNOP00000084566.2, ENSRNOT00000099238.2

  16. XM_063281116.1 → XP_063137186.1  microtubule-associated serine/threonine-protein kinase 4 isoform X11

  17. XM_063281130.1 → XP_063137200.1  microtubule-associated serine/threonine-protein kinase 4 isoform X26

  18. XM_063281125.1 → XP_063137195.1  microtubule-associated serine/threonine-protein kinase 4 isoform X20

  19. XM_063281129.1 → XP_063137199.1  microtubule-associated serine/threonine-protein kinase 4 isoform X24

  20. XM_063281123.1 → XP_063137193.1  microtubule-associated serine/threonine-protein kinase 4 isoform X17

    UniProtKB/TrEMBL
    F1M4F3
    Related
    ENSRNOP00000057748.5, ENSRNOT00000061032.6

  21. XM_063281119.1 → XP_063137189.1  microtubule-associated serine/threonine-protein kinase 4 isoform X13

  22. XM_063281121.1 → XP_063137191.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

  23. XM_063281126.1 → XP_063137196.1  microtubule-associated serine/threonine-protein kinase 4 isoform X21

  24. XM_008760705.4 → XP_008758927.1  microtubule-associated serine/threonine-protein kinase 4 isoform X25

    See identical proteins and their annotated locations for XP_008758927.1

    UniProtKB/TrEMBL
    A0A8I5Y716
    Conserved Domains (4) summary
    smart00220
    Location:376 → 649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:885 → 963
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375 → 654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64 → 337
    DUF1908; Domain of unknown function (DUF1908)

  25. XM_008760704.4 → XP_008758926.1  microtubule-associated serine/threonine-protein kinase 4 isoform X18

    See identical proteins and their annotated locations for XP_008758926.1

    UniProtKB/TrEMBL
    A0A8I5Y716, M0R3L1
    Related
    ENSRNOP00000112402.1, ENSRNOT00000153138.1
    Conserved Domains (4) summary
    smart00220
    Location:376 → 649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:952 → 1030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375 → 654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64 → 337
    DUF1908; Domain of unknown function (DUF1908)

  26. XM_063281128.1 → XP_063137198.1  microtubule-associated serine/threonine-protein kinase 4 isoform X23

  27. XM_063281127.1 → XP_063137197.1  microtubule-associated serine/threonine-protein kinase 4 isoform X22

    Related
    ENSRNOP00000063928.3, ENSRNOT00000074941.4
Nucleotide Protein Strain
Heading Accession and Version

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