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Plekho2 pleckstrin homology domain containing, family O member 2 [ Mus musculus (house mouse) ]

Gene ID: 102595, updated on 27-Nov-2024

Summary

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Official Symbol
Plekho2provided by MGI
Official Full Name
pleckstrin homology domain containing, family O member 2provided by MGI
Primary source
MGI:MGI:2143132
See related
Ensembl:ENSMUSG00000050721 AllianceGenome:MGI:2143132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plekhq1
Summary
Acts upstream of or within macrophage apoptotic process. Orthologous to human PLEKHO2 (pleckstrin homology domain containing O2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen adult (RPKM 18.7), adrenal adult (RPKM 15.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Plekho2 in Genome Data Viewer
Location:
9 C; 9 35.38 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65459859..65487369, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65552577..65580087, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene SPG21, maspardin Neighboring gene ankyrin repeat and death domain containing 1A Neighboring gene STARR-seq mESC enhancer starr_24454 Neighboring gene predicted gene, 17749 Neighboring gene STARR-positive B cell enhancer ABC_E2896 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65389334-65389517 Neighboring gene STARR-positive B cell enhancer ABC_E2897 Neighboring gene STARR-positive B cell enhancer ABC_E9331 Neighboring gene STARR-seq mESC enhancer starr_24458 Neighboring gene STARR-positive B cell enhancer ABC_E892 Neighboring gene STARR-positive B cell enhancer ABC_E2898 Neighboring gene PIF1 5'-to-3' DNA helicase Neighboring gene predicted pseudogene 10144

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PLEKHO2 inhibits TNFα-induced cell death by suppressing RIPK1 activation. Zhou C, et al. Cell Death Dis, 2021 Jul 16. PMID 34272357, Free PMC Article
  2. PLEKHO2 is essential for M-CSF-dependent macrophage survival. Zhang P, et al. Cell Signal, 2017 Sep. PMID 28627369
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30448

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in macrophage apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within macrophage apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family O member 2
Names
PH domain-containing family O member 2
PH domain-containing family Q member 1
PH domain-containing protein homolog
pleckstrin homology domain containing, family Q member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153119.3 → NP_694759.1  pleckstrin homology domain-containing family O member 2

    See identical proteins and their annotated locations for NP_694759.1

    Status: VALIDATED

    Source sequence(s)
    AC135108, AK028069, AK158288, BY193678
    Consensus CDS
    CCDS23294.1
    UniProtKB/Swiss-Prot
    Q3TCY2, Q3U4R2, Q8C1F2, Q8K124, Q8R140
    Related
    ENSMUSP00000063677.8, ENSMUST00000068944.9
    Conserved Domains (2) summary
    cd13317
    Location:15 → 115
    PH_PLEKHO1_PLEKHO2; Pleckstrin homology domain-containing family O Pleckstrin homology domain
    pfam00169
    Location:21 → 119
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65459859..65487369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313067.3 → XP_017168556.1  pleckstrin homology domain-containing family O member 2 isoform X2

  2. XM_017313066.2 → XP_017168555.1  pleckstrin homology domain-containing family O member 2 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:138 → 399
    PHA03247; large tegument protein UL36; Provisional
    cl17171
    Location:83 → 104
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K124.1 GenPept UniProtKB/Swiss-Prot:Q8K124

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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