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RANGAP2 Ran GTPase-activating protein 2 [ Solanum tuberosum (potato) ]

Gene ID: 102577808, updated on 2-Nov-2023

Summary

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Gene symbol
RANGAP2
Gene description
Ran GTPase-activating protein 2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Solanum tuberosum
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
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Genomic context

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See RANGAP2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
2
Annotation release Status Assembly Chr Location
101 current SolTub_3.0 (GCF_000226075.1) Unplaced Scaffold NW_006239030.1 (1213915..1216916)

NW_006239030.1Genomic Context describing neighboring genes Neighboring gene CTP synthase-like Neighboring gene uncharacterized LOC102579218 Neighboring gene uncharacterized LOC107060921 Neighboring gene probable ATP-dependent DNA helicase CHR12 Neighboring gene peroxisome biogenesis protein 7-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006239030.1 Unplaced Scaffold Reference SolTub_3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis for the interaction between the potato virus X resistance protein (Rx) and its cofactor Ran GTPase-activating protein 2 (RanGAP2). Hao W, et al. J Biol Chem, 2013 Dec 13. PMID 24194517, Free PMC Article
  2. Evolution and variability of Solanum RanGAP2, a cofactor in the incompatible interaction between the resistance protein GPA2 and the Globodera pallida effector Gp-RBP-1. Carpentier J, et al. BMC Evol Biol, 2013 Apr 19. PMID 23601377, Free PMC Article
  3. Divergent evolution of potato immune receptor CC domain interactions with the Ran GTPase-activating protein 2. Sobhanian S, et al. Plant Signal Behav, 2014. PMID 25763710, Free PMC Article
  4. A RanGAP protein physically interacts with the NB-LRR protein Rx, and is required for Rx-mediated viral resistance. Sacco MA, et al. Plant J, 2007 Oct. PMID 17655649
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings substantiate the importance of RanGAP2 as a common CC-interacting protein of multiple immune receptors requiring further study to define their roles in pathogen perception
    Title: Divergent evolution of potato immune receptor CC domain interactions with the Ran GTPase-activating protein 2.
  2. RanGap2 genetic variability does not influence the specificity of GPA2 recognition but is able to modulate this activity by enhancing the defence response.
    Title: Evolution and variability of Solanum RanGAP2, a cofactor in the incompatible interaction between the resistance protein GPA2 and the Globodera pallida effector Gp-RBP-1.
  3. molecular mechanism underlying the interaction of Rx with RanGAP2
    Title: Structural basis for the interaction between the potato virus X resistance protein (Rx) and its cofactor Ran GTPase-activating protein 2 (RanGAP2).
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
Ran GTPase-activating protein 2; ran GTPase-activating protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288250.1 → NP_001275179.1  Ran GTPase-activating protein 2

    See identical proteins and their annotated locations for NP_001275179.1

    Status: PROVISIONAL

    Source sequence(s)
    AM411448
    UniProtKB/TrEMBL
    A7M8K2, I7ILS8
    Conserved Domains (3) summary
    cd00116
    Location:183 → 449
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:216 → 243
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13943
    Location:15 → 109
    WPP; WPP domain

RefSeqs of Annotated Genomes: Solanum tuberosum Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference SolTub_3.0 Primary Assembly

Genomic

  1. NW_006239030.1 Reference SolTub_3.0 Primary Assembly

    Range
    1213915..1216916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006349150.2 → XP_006349212.1  ran GTPase-activating protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006349212.1

    UniProtKB/TrEMBL
    I7ICB4, I7ILN7, I7JNX9, M1AI54
    Conserved Domains (4) summary
    COG5238
    Location:125 → 532
    RNA1; Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification]
    cd00116
    Location:131 → 443
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:183 → 215
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13943
    Location:15 → 109
    WPP; WPP domain

  2. XM_006349151.2 → XP_006349213.1  ran GTPase-activating protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006349213.1

    UniProtKB/TrEMBL
    I7ICB4, I7ILN7, I7JNX9, M1AI54
    Conserved Domains (4) summary
    COG5238
    Location:125 → 532
    RNA1; Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification]
    cd00116
    Location:131 → 443
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:183 → 215
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13943
    Location:15 → 109
    WPP; WPP domain
Nucleotide Protein
Heading Accession and Version

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