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plex9.1 PML-like exon 9.1 [ Danio rerio (zebrafish) ]

Gene ID: 101886651, updated on 4-Jan-2025

Summary

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Official Symbol
plex9.1provided by ZNC
Official Full Name
PML-like exon 9.1provided by ZNC
Primary source
ZFIN:ZDB-GENE-131127-357
See related
Ensembl:ENSDARG00000092584 AllianceGenome:ZFIN:ZDB-GENE-131127-357
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
trex3; si:ch1073-385f13.3
Summary
Predicted to enable 3'-5'-DNA exonuclease activity. Predicted to be involved in DNA catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1) and TREX2 (three prime repair exonuclease 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See plex9.1 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (477970..483582, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (457025..461009, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene protogenin homolog b (Gallus gallus) Neighboring gene ribosomal L24 domain containing 1 Neighboring gene myosin IXAb Neighboring gene neural EGFL like 2a Neighboring gene uncharacterized LOC137489306

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates. Mathavarajah S, et al. Nucleic Acids Res, 2023 Apr 24. PMID 36912092, Free PMC Article
  2. IFN-Stimulated Genes in Zebrafish and Humans Define an Ancient Arsenal of Antiviral Immunity. Levraud JP, et al. J Immunol, 2019 Dec 15. PMID 31732531
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables 3'-5'-DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA 3'-5' DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA polymerase III subunit epsilon
Names
three prime repair exonuclease 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    477970..483582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005174215.5 → XP_005174272.1  DNA polymerase III subunit epsilon

    UniProtKB/TrEMBL
    A0A8M2BLG7, E7FAN2
    Related
    ENSDARP00000095491.2, ENSDART00000104720.4
    Conserved Domains (2) summary
    cd06127
    Location:58 → 228
    DEDDh; DEDDh 3'-5' exonuclease domain family
    COG0847
    Location:54 → 244
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials