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si:ch73-383l1.1 si:ch73-383l1.1 [ Danio rerio (zebrafish) ]

Gene ID: 101885162, updated on 9-Dec-2024

Summary

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Official Symbol
si:ch73-383l1.1provided by ZNC
Official Full Name
si:ch73-383l1.1provided by ZNC
Primary source
ZFIN:ZDB-GENE-121214-64
See related
Ensembl:ENSDARG00000090408 AllianceGenome:ZFIN:ZDB-GENE-121214-64
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch73-162k10.1
Summary
Predicted to enable epidermal growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See si:ch73-383l1.1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (7190016..7456337)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (6584380..6765655)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108184914 Neighboring gene U6 spliceosomal RNA Neighboring gene LanC antibiotic synthetase component C-like 1 (bacterial) Neighboring gene myosin, light polypeptide 3, skeletal muscle

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos. Paatero I, et al. Mol Biol Cell, 2019 Jan 15. PMID 30462579, Free PMC Article
  2. Conservation and early expression of zebrafish tyrosine kinases support the utility of zebrafish as a model for tyrosine kinase biology. Challa AK, et al. Zebrafish, 2013 Sep. PMID 23234507, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERBB signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor tyrosine-protein kinase erbB-4; si:ch73-383l1.1
Names
erbb4d
receptor tyrosine-protein kinase erbB-4-like
XP_021331611.1
XP_068077088.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    7190016..7456337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021475936.2 → XP_021331611.1  receptor tyrosine-protein kinase erbB-4 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q7Y5
    Related
    ENSDARP00000086547.8, ENSDART00000092114.8
    Conserved Domains (5) summary
    cd12092
    Location:631 → 674
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    pfam00757
    Location:183 → 331
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:54 → 166
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:501 → 633
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:699 → 995
    PKc_like; Protein Kinases, catalytic domain

  2. XM_068220987.1 → XP_068077088.1  receptor tyrosine-protein kinase erbB-4 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials