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Mzt1 Mitotic spindle organizing protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 10178948, updated on 9-Dec-2024

Summary

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Official Symbol
Mzt1provided by FlyBase
Official Full Name
Mitotic spindle organizing protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0261858
Locus tag
Dmel_CG42787
See related
AllianceGenome:FB:FBgn0261858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG42787; Dmel\CG42787; mzt1
Summary
Enables gamma-tubulin binding activity. Involved in gamma-tubulin complex localization. Located in centriole; centrosome; and cytoplasmic side of mitochondrial outer membrane. Part of gamma-tubulin ring complex. Is expressed in gonad and male germline cell. Orthologous to human MZT1 (mitotic spindle organizing protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Mzt1 in Genome Data Viewer
Location:
62E1-62E1; 3-3 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2389265..2389650)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2389265..2389650)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Supervillin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4d20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The gamma-tubulin ring complex: Deciphering the molecular organization and assembly mechanism of a major vertebrate microtubule nucleator. Böhler A, et al. Bioessays, 2021 Aug. PMID 34160844
  2. γ-TuRC Heterogeneity Revealed by Analysis of Mozart1. Tovey CA, et al. Curr Biol, 2018 Jul 23. PMID 29983314, Free PMC Article
  3. Microtubule Organizing Centers Contain Testis-Specific γ-TuRC Proteins in Spermatids of Drosophila. Alzyoud E, et al. Front Cell Dev Biol, 2021. PMID 34660584, Free PMC Article
  4. Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach. Hall BS, et al. Aging (Albany NY), 2019 Dec 3. PMID 31794428, Free PMC Article
  5. A genetic interaction map of cell cycle regulators. Billmann M, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912791, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in gamma-tubulin complex localization IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-tubulin complex localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule nucleation by interphase microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin ring complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin ring complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin ring complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in interphase microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitotic spindle organizing protein 1
Names
CG42787-PA
MOZART1
Mzt1-PA
mitotic spindle OrganiZing protein associated with a ring of g-Tubulin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    2389265..2389650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202099.2 → NP_001189028.1  mitotic spindle organizing protein 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189028.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6ILY6
    Conserved Domains (1) summary
    pfam12554
    Location:14 → 56
    MOZART1; Mitotic-spindle organizing gamma-tubulin ring associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ILY6 Q6ILY6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials