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Plekhg2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 [ Mus musculus (house mouse) ]

Gene ID: 101497, updated on 27-Nov-2024

Summary

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Official Symbol
Plekhg2provided by MGI
Official Full Name
pleckstrin homology domain containing, family G (with RhoGef domain) member 2provided by MGI
Primary source
MGI:MGI:2141874
See related
Ensembl:ENSMUSG00000037552 AllianceGenome:MGI:2141874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clg; Cslg
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of actin filament polymerization. Orthologous to human PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 36.3), spleen adult (RPKM 18.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Plekhg2 in Genome Data Viewer
Location:
7 A3; 7 16.71 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28059028..28072818, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28359603..28372681, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene suppressor of Ty 5, DSIF elongation factor subunit Neighboring gene STARR-seq mESC enhancer starr_18409 Neighboring gene STARR-positive B cell enhancer ABC_E3708 Neighboring gene snoRNA AF357399 Neighboring gene ribosomal protein S16 Neighboring gene STARR-positive B cell enhancer ABC_E445 Neighboring gene STARR-positive B cell enhancer ABC_E1728 Neighboring gene STARR-seq mESC enhancer starr_18413 Neighboring gene nuclear encoded tRNA isoleucine 16 (anticodon TAT) Neighboring gene STARR-positive B cell enhancer ABC_E2821 Neighboring gene STARR-seq mESC enhancer starr_18414 Neighboring gene Paf1, RNA polymerase II complex component Neighboring gene zinc finger protein 36 Neighboring gene STARR-positive B cell enhancer ABC_E289 Neighboring gene mediator complex subunit 29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes. Nishikawa M, et al. Cells, 2022 Feb 16. PMID 35203342, Free PMC Article
  2. Expression analyses of PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, during mouse brain development. Nishikawa M, et al. Med Mol Morphol, 2021 Jun. PMID 33492483
  3. Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias. Himmel KL, et al. J Biol Chem, 2002 Apr 19. PMID 11839748
  4. Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Chai G, et al. Neuron, 2021 Jan 20. PMID 33220177, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression analyses of PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, during mouse brain development.
    Title: Expression analyses of PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, during mouse brain development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family G member 2
Names
PH domain-containing family G member 2
common site lymphoma/leukemia guanine nucleotide exchange factor
common-site lymphoma/leukemia GEF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083912.2 → NP_001077381.1  pleckstrin homology domain-containing family G member 2 isoform b

    See identical proteins and their annotated locations for NP_001077381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a small in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC149606
    Consensus CDS
    CCDS52162.1
    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    UniProtKB/TrEMBL
    G5E8T4
    Related
    ENSMUSP00000112881.2, ENSMUST00000119990.8
    Conserved Domains (2) summary
    cd13243
    Location:259 → 409
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:102 → 277
    RhoGEF; RhoGEF domain

  2. NM_001290542.2 → NP_001277471.1  pleckstrin homology domain-containing family G member 2 isoform b

    See identical proteins and their annotated locations for NP_001277471.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks a small in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC149606
    Consensus CDS
    CCDS52162.1
    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    UniProtKB/TrEMBL
    G5E8T4
    Conserved Domains (2) summary
    cd13243
    Location:259 → 409
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:102 → 277
    RhoGEF; RhoGEF domain

  3. NM_138752.3 → NP_620091.2  pleckstrin homology domain-containing family G member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC149606
    Consensus CDS
    CCDS21040.2
    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    UniProtKB/TrEMBL
    E9QKB6
    Related
    ENSMUSP00000092228.5, ENSMUST00000094644.11
    Conserved Domains (2) summary
    cd13243
    Location:260 → 410
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:103 → 278
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28059028..28072818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539439.5 → XP_006539502.1  pleckstrin homology domain-containing family G member 2 isoform X2

    See identical proteins and their annotated locations for XP_006539502.1

    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    UniProtKB/TrEMBL
    D3Z5N8
    Conserved Domains (3) summary
    PTZ00449
    Location:350 → 741
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd13243
    Location:259 → 409
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:102 → 277
    RhoGEF; RhoGEF domain

  2. XM_006539437.5 → XP_006539500.1  pleckstrin homology domain-containing family G member 2 isoform X2

    See identical proteins and their annotated locations for XP_006539500.1

    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    UniProtKB/TrEMBL
    D3Z5N8
    Related
    ENSMUSP00000113449.2, ENSMUST00000121085.8
    Conserved Domains (3) summary
    PTZ00449
    Location:350 → 741
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd13243
    Location:259 → 409
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:102 → 277
    RhoGEF; RhoGEF domain

  3. XM_011250408.4 → XP_011248710.1  pleckstrin homology domain-containing family G member 2 isoform X1

    See identical proteins and their annotated locations for XP_011248710.1

    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    Conserved Domains (3) summary
    PTZ00449
    Location:351 → 742
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd13243
    Location:260 → 410
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:103 → 278
    RhoGEF; RhoGEF domain

  4. XM_030241941.2 → XP_030097801.1  pleckstrin homology domain-containing family G member 2 isoform X5

    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    Conserved Domains (3) summary
    PTZ00449
    Location:308 → 699
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd13243
    Location:217 → 367
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:60 → 235
    RhoGEF; RhoGEF domain

  5. XM_006539441.4 → XP_006539504.1  pleckstrin homology domain-containing family G member 2 isoform X5

    See identical proteins and their annotated locations for XP_006539504.1

    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    Conserved Domains (3) summary
    PTZ00449
    Location:308 → 699
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd13243
    Location:217 → 367
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:60 → 235
    RhoGEF; RhoGEF domain

  6. XM_036152530.1 → XP_036008423.1  pleckstrin homology domain-containing family G member 2 isoform X5

    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    Conserved Domains (3) summary
    PTZ00449
    Location:308 → 699
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd13243
    Location:217 → 367
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:60 → 235
    RhoGEF; RhoGEF domain

  7. XM_036152531.1 → XP_036008424.1  pleckstrin homology domain-containing family G member 2 isoform X5

    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    Conserved Domains (3) summary
    PTZ00449
    Location:308 → 699
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd13243
    Location:217 → 367
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:60 → 235
    RhoGEF; RhoGEF domain

  8. XM_036152534.1 → XP_036008427.1  pleckstrin homology domain-containing family G member 2 isoform X6

    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    Conserved Domains (2) summary
    cd13243
    Location:217 → 367
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:60 → 235
    RhoGEF; RhoGEF domain

  9. XM_036152532.1 → XP_036008425.1  pleckstrin homology domain-containing family G member 2 isoform X6

    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    Related
    ENSMUST00000128015.8
    Conserved Domains (2) summary
    cd13243
    Location:217 → 367
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:60 → 235
    RhoGEF; RhoGEF domain

  10. XM_036152533.1 → XP_036008426.1  pleckstrin homology domain-containing family G member 2 isoform X6

    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    Conserved Domains (2) summary
    cd13243
    Location:217 → 367
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:60 → 235
    RhoGEF; RhoGEF domain

  11. XM_006539436.5 → XP_006539499.1  pleckstrin homology domain-containing family G member 2 isoform X1

    See identical proteins and their annotated locations for XP_006539499.1

    UniProtKB/Swiss-Prot
    A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
    Conserved Domains (3) summary
    PTZ00449
    Location:351 → 742
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd13243
    Location:260 → 410
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:103 → 278
    RhoGEF; RhoGEF domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6KAU7.2 GenPept UniProtKB/Swiss-Prot:Q6KAU7

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