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OAZ3 ornithine decarboxylase antizyme 3 [ Orcinus orca (killer whale) ]

Gene ID: 101283720, updated on 10-May-2024

Summary

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Gene symbol
OAZ3
Gene description
ornithine decarboxylase antizyme 3
See related
EnsemblRapid:ENSOORG00010019040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been noted for this gene. [provided by RefSeq, Aug 2014]
Orthologs
human mouse all
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Genomic context

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See OAZ3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 1 NC_064559.1 (103303821..103310278, complement)

Chromosome 1 - NC_064559.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 4 Neighboring gene tudor and KH domain containing Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene regulatory subunit of type II PKA R-subunit domain containing 1 Neighboring gene CUGBP Elav-like family member 3 Neighboring gene sorting nexin 27 Neighboring gene protein FAM117A-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064559.1 Chromosome 1 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polyamines in spermiogenesis: not now, darling. Coffino P. Proc Natl Acad Sci U S A, 2000 Apr 25. PMID 10781034, Free PMC Article
  2. Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation. Ivanov IP, et al. Nucleic Acids Res, 2007. PMID 17332016, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ornithine decarboxylase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ornithine decarboxylase antizyme 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290373.1 → NP_001277302.1  ornithine decarboxylase antizyme 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation from an AUG start codon, compared to variant 1. The resulting isoform (2) is shorter with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    OW443360
    Related
    ENSOORP00010025065.1, ENSOORT00010028493.1
    Conserved Domains (1) summary
    pfam02100
    Location:82 → 178
    ODC_AZ; Ornithine decarboxylase antizyme

  2. NM_001301420.1 → NP_001288349.1  ornithine decarboxylase antizyme 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) initiates translation from a non-AUG (CUG) start codon, and encodes the longer isoform (1).
    Source sequence(s)
    OW443360
    Related
    ENSOORP00010025063.1, ENSOORT00010028491.1
    Conserved Domains (1) summary
    pfam02100
    Location:126 → 222
    ODC_AZ; Ornithine decarboxylase antizyme

RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064559.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    103303821..103310278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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