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NOTCH3 notch receptor 3 [ Ovis aries (sheep) ]

Gene ID: 101123554, updated on 8-Mar-2024

Summary

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Gene symbol
NOTCH3
Gene description
notch receptor 3
See related
EnsemblRapid:ENSOARG00020003788
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See NOTCH3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 5 NC_056058.1 (7738979..7777400)

Chromosome 5 - NC_056058.1Genomic Context describing neighboring genes Neighboring gene bromodomain containing 4 Neighboring gene epoxide hydrolase 3 Neighboring gene MKI67 FHA domain-interacting nucleolar phosphoprotein-like Neighboring gene olfactory receptor 10T2-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056058.1 Chromosome 5 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurogenic locus notch homolog protein 3
Names
notch 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056058.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    7738979..7777400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027979127.2 → XP_027834928.1  neurogenic locus notch homolog protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A836AFF6
    Related
    ENSOARP00020004757.2, ENSOART00020005774.2

  2. XM_042249771.2 → XP_042105705.1  neurogenic locus notch homolog protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A836AFF6
    Conserved Domains (6) summary
    smart00004
    Location:1324 → 1361
    NL; Domain found in Notch and Lin-12
    smart00179
    Location:592 → 621
    EGF_CA; Calcium-binding EGF-like domain
    PHA03247
    Location:2010 → 2263
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:1802 → 1968
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:93 → 130
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1849 → 1880
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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