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Tshz2 teashirt zinc finger homeobox 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100911757, updated on 4-Jan-2025

Summary

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Official Symbol
Tshz2provided by RGD
Official Full Name
teashirt zinc finger homeobox 2provided by RGD
Primary source
RGD:6490867
See related
EnsemblRapid:ENSRNOG00000048433 AllianceGenome:RGD:6490867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of gene expression. Predicted to be active in nucleus. Orthologous to human TSHZ2 (teashirt zinc finger homeobox 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Uterus (RPKM 57.4), Heart (RPKM 56.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tshz2 in Genome Data Viewer
Location:
3q42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (178824221..179271151)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (158405469..158666915)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (166469752..166748558)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486487 Neighboring gene uncharacterized LOC134486316 Neighboring gene uncharacterized LOC103691977 Neighboring gene uncharacterized LOC102556304 Neighboring gene uncharacterized LOC120101800 Neighboring gene uncharacterized LOC134486489 Neighboring gene uncharacterized LOC120101801 Neighboring gene uncharacterized LOC134486488 Neighboring gene uncharacterized LOC134486490 Neighboring gene uncharacterized LOC120101802 Neighboring gene U2 spliceosomal RNA Neighboring gene zinc finger protein 217 Neighboring gene uncharacterized LOC108350531

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex. Bedogni F, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20615956, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
teashirt homolog 2
Names
teashirt homolog 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399744.2 → NP_001386673.1  teashirt homolog 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JXR9
    Related
    ENSRNOP00000100859.1, ENSRNOT00000149850.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    178824221..179271151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282975.1 → XP_063139045.1  teashirt homolog 2 isoform X4

    UniProtKB/TrEMBL
    A6JXR9, M0R6R4
    Related
    ENSRNOP00000101361.1, ENSRNOT00000131007.1

  2. XM_039106732.2 → XP_038962660.1  teashirt homolog 2 isoform X1

    UniProtKB/TrEMBL
    A6JXR9
    Related
    ENSRNOP00000065119.3, ENSRNOT00000073788.3
    Conserved Domains (2) summary
    cd00086
    Location:861 → 929
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:241 → 263
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_063282974.1 → XP_063139044.1  teashirt homolog 2 isoform X3

    UniProtKB/TrEMBL
    A6JXR9

  4. XM_063282976.1 → XP_063139046.1  teashirt homolog 2 isoform X5

    UniProtKB/TrEMBL
    A6JXR9

  5. XM_039106734.2 → XP_038962662.1  teashirt homolog 2 isoform X2

    UniProtKB/TrEMBL
    A6JXR9
    Related
    ENSRNOP00000108262.1, ENSRNOT00000142962.1
    Conserved Domains (2) summary
    cd00086
    Location:835 → 903
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:215 → 237
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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