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Cfap69 cilia and flagella associated protein 69 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100910867, updated on 4-Jan-2025

Summary

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Official Symbol
Cfap69provided by RGD
Official Full Name
cilia and flagella associated protein 69provided by RGD
Primary source
RGD:6496360
See related
EnsemblRapid:ENSRNOG00000006114 AllianceGenome:RGD:6496360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including positive regulation of fertilization; positive regulation of flagellated sperm motility; and response to odorant. Predicted to act upstream of or within sperm axoneme assembly. Predicted to be located in cytoplasm. Predicted to be active in non-motile cilium and sperm midpiece. Human ortholog(s) of this gene implicated in spermatogenic failure 24. Orthologous to human CFAP69 (cilia and flagella associated protein 69). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 151.3), Brain (RPKM 43.7) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cfap69 in Genome Data Viewer
Location:
4q13
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (29334624..29405513)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (28379604..28452562)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (25538513..25611470)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene STEAP family member 1 Neighboring gene STEAP2 metalloreductase Neighboring gene uncharacterized LOC134486556 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene family with sequence similarity 237 member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse. Dong FN, et al. Am J Hum Genet, 2018 Apr 5. PMID 29606301, Free PMC Article
  2. Cilia- and Flagella-Associated Protein 69 Regulates Olfactory Transduction Kinetics in Mice. Talaga AK, et al. J Neurosci, 2017 Jun 7. PMID 28495971, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC72627

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in olfactory behavior IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in olfactory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fertilization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in response to odorant IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to odorant ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sperm axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in non-motile cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in sperm midpiece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cilia and flagella associated protein 69; cilia- and flagella-associated protein 69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431973.1 → NP_001418902.1  cilia and flagella associated protein 69 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AJA3

  2. NM_001431974.1 → NP_001418903.1  cilia and flagella associated protein 69 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AJA3

  3. NM_001431975.1 → NP_001418904.1  cilia and flagella associated protein 69 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AJA3

  4. NM_001431976.1 → NP_001418905.1  cilia and flagella associated protein 69 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AJA3

  5. NM_001431977.1 → NP_001418906.1  cilia and flagella associated protein 69 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  6. NM_001431978.1 → NP_001418907.1  cilia and flagella associated protein 69 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  7. NM_001431979.1 → NP_001418908.1  cilia and flagella associated protein 69 isoform f

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    Q6P6X4

  8. NM_001431980.1 → NP_001418909.1  cilia and flagella associated protein 69 isoform g

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  9. NM_001431981.1 → NP_001418910.1  cilia and flagella associated protein 69 isoform h

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RNA

  1. NR_197254.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  2. NR_197255.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  3. NR_197256.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  4. NR_197257.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  5. NR_197258.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  6. NR_197259.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  7. NR_197260.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  8. NR_197261.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  9. NR_197262.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    29334624..29405513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003749688.6 → XP_003749736.1  cilia- and flagella-associated protein 69 isoform X1

    Related
    ENSRNOP00000093632.2, ENSRNOT00000112626.2

  2. XM_063286814.1 → XP_063142884.1  cilia- and flagella-associated protein 69 isoform X2

  3. XM_008762733.4 → XP_008760955.1  cilia- and flagella-associated protein 69 isoform X2

  4. XM_008762734.4 → XP_008760956.1  cilia- and flagella-associated protein 69 isoform X2

    See identical proteins and their annotated locations for XP_008760956.1

    UniProtKB/TrEMBL
    A0A8I6AJA3

  5. XM_006236074.5 → XP_006236136.1  cilia- and flagella-associated protein 69 isoform X3

  6. XM_039108576.2 → XP_038964504.1  cilia- and flagella-associated protein 69 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007644.1: Suppressed sequence

    Description
    NM_001007644.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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