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Rita1 RBPJ interacting and tubulin associated 1 [ Mus musculus (house mouse) ]

Gene ID: 100764, updated on 27-Nov-2024

Summary

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Official Symbol
Rita1provided by MGI
Official Full Name
RBPJ interacting and tubulin associated 1provided by MGI
Primary source
MGI:MGI:1922021
See related
Ensembl:ENSMUSG00000029600 AllianceGenome:MGI:1922021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rita; 1110008J03Rik
Summary
Predicted to enable tubulin binding activity. Predicted to be involved in negative regulation of Notch signaling pathway; neurogenesis; and nuclear export. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human RITA1 (RBPJ interacting and tubulin associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 13.5), stomach adult (RPKM 12.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rita1 in Genome Data Viewer
Location:
5 F; 5 60.63 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120747123..120750654, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120609058..120612589, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2173 Neighboring gene solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 Neighboring gene two pore channel 1 Neighboring gene STARR-seq mESC enhancer starr_14239 Neighboring gene STARR-positive B cell enhancer ABC_E57 Neighboring gene IQ motif containing D Neighboring gene STARR-positive B cell enhancers ABC_E2760 and ABC_E2174 Neighboring gene STARR-positive B cell enhancer ABC_E3610 Neighboring gene DEAD box helicase 54 Neighboring gene cilia and flagella associated protein 73 Neighboring gene STARR-positive B cell enhancer ABC_E4782 Neighboring gene RAS protein activator like 1 (GAP1 like) Neighboring gene STARR-positive B cell enhancer ABC_E11300

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics. Steinhäuser K, et al. Oncogene, 2017 Apr. PMID 27721410
  2. Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes. Tabaja N, et al. J Biol Chem, 2017 Jun 23. PMID 28487372, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nuclear export IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear export IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear export ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
RBPJ-interacting and tubulin-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029096.3 → NP_083372.1  RBPJ-interacting and tubulin-associated protein 1

    See identical proteins and their annotated locations for NP_083372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC125183, AI850520, AK003581
    Consensus CDS
    CCDS51635.1
    UniProtKB/Swiss-Prot
    Q9D1H0
    Related
    ENSMUSP00000031599.3, ENSMUST00000031599.9
    Conserved Domains (1) summary
    pfam17066
    Location:1 → 253
    RITA; RBPJ-interacting and tubulin associated protein

  2. NM_133908.1 → NP_598669.1  RBPJ-interacting and tubulin-associated protein 1

    See identical proteins and their annotated locations for NP_598669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC125183, CX239969
    Consensus CDS
    CCDS51635.1
    UniProtKB/Swiss-Prot
    Q9D1H0
    Related
    ENSMUSP00000136946.2, ENSMUST00000177800.8
    Conserved Domains (1) summary
    pfam17066
    Location:1 → 253
    RITA; RBPJ-interacting and tubulin associated protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    120747123..120750654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1H0.1 GenPept UniProtKB/Swiss-Prot:Q9D1H0

Gene LinkOut

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