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Rell1 RELT-like 1 [ Mus musculus (house mouse) ]

Gene ID: 100532, updated on 27-Nov-2024

Summary

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Official Symbol
Rell1provided by MGI
Official Full Name
RELT-like 1provided by MGI
Primary source
MGI:MGI:2140767
See related
Ensembl:ENSMUSG00000047881 AllianceGenome:MGI:2140767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in positive regulation of p38MAPK cascade. Predicted to be located in microtubule cytoskeleton. Predicted to be active in plasma membrane. Is expressed in retina. Orthologous to human RELL1 (RELT like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 8.9), adrenal adult (RPKM 7.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Rell1 in Genome Data Viewer
Location:
5 C3.1; 5 32.8 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (64047296..64126165, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (63889337..63969020, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13178 Neighboring gene NACHT and WD repeat domain containing 2, opposite strand Neighboring gene NACHT and WD repeat domain containing 2 Neighboring gene hematological and neurological expressed 1 protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_13179 Neighboring gene RIKEN cDNA 0610040J01 gene Neighboring gene STARR-positive B cell enhancer ABC_E8053 Neighboring gene STARR-seq mESC enhancer starr_13182 Neighboring gene STARR-seq mESC enhancer starr_13187 Neighboring gene STARR-positive B cell enhancer ABC_E8054 Neighboring gene STARR-seq mESC enhancer starr_13191 Neighboring gene STARR-seq mESC enhancer starr_13192 Neighboring gene STARR-seq mESC enhancer starr_13193 Neighboring gene predicted gene, 25608 Neighboring gene RIKEN cDNA 5830416I19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr5:64431930-64432231

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RELL1 inhibits autophagy pathway and regulates Mycobacterium tuberculosis survival in macrophages. Feng L, et al. Tuberculosis (Edinb), 2020 Jan. PMID 32090861
  2. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RELL1 inhibits autophagy pathway and regulates Mycobacterium tuberculosis survival in macrophages.
    Title: RELL1 inhibits autophagy pathway and regulates Mycobacterium tuberculosis survival in macrophages.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RELT-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417949.1 → NP_001404878.1  RELT-like protein 1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC158789
    UniProtKB/Swiss-Prot
    Q3TVW8, Q3UZH6, Q8K2J7, Q8R3S5

  2. NM_001417950.1 → NP_001404879.1  RELT-like protein 1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC158789
    UniProtKB/Swiss-Prot
    Q3TVW8, Q3UZH6, Q8K2J7, Q8R3S5

  3. NM_001417951.1 → NP_001404880.1  RELT-like protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158789

  4. NM_145923.5 → NP_666035.2  RELT-like protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_666035.2

    Status: VALIDATED

    Source sequence(s)
    AC158789
    Consensus CDS
    CCDS39093.1
    UniProtKB/Swiss-Prot
    Q3TVW8, Q3UZH6, Q8K2J7, Q8R3S5
    Related
    ENSMUSP00000118125.2, ENSMUST00000154169.4
    Conserved Domains (1) summary
    pfam12606
    Location:59 → 91
    RELT; tumor necrosis factor receptor superfamily member 19

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    64047296..64126165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2J7.2 GenPept UniProtKB/Swiss-Prot:Q8K2J7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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