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EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 100428309, updated on 17-Aug-2024

Summary

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Official Symbol
EIF2AK4provided by VGNC
Official Full Name
eukaryotic translation initiation factor 2 alpha kinase 4provided by VGNC
Primary source
VGNC:VGNC:84337
See related
Ensembl:ENSMMUG00000038966
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See EIF2AK4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
41
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (16346151..16453158)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (16255325..16363582)

Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 176 Neighboring gene uncharacterized LOC106999142 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC114679379 Neighboring gene uncharacterized LOC106999143 Neighboring gene signal recognition particle 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection. Jiang G, et al. mBio, 2017 May 2. PMID 28465428, Free PMC Article
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of translational initiation by eIF2 alpha phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 2-alpha kinase 4; eIF-2-alpha kinase GCN2
XP_014997405.2
XP_014997406.2
XP_014997409.2
XP_028706564.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041760.1 Reference Mmul_10 Primary Assembly

    Range
    16346151..16453158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015141920.2 → XP_014997406.2  eIF-2-alpha kinase GCN2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5Q5J7, A0A5F8AAT7
    Related
    ENSMMUP00000043313.2, ENSMMUT00000078593.2
    Conserved Domains (4) summary
    PLN02972
    Location:1071 → 1491
    PLN02972; Histidyl-tRNA synthetase
    cd14012
    Location:299 → 538
    PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cd14046
    Location:583 → 999
    STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    pfam05773
    Location:21 → 134
    RWD; RWD domain

  2. XM_015141923.2 → XP_014997409.2  eIF-2-alpha kinase GCN2 isoform X4

    UniProtKB/TrEMBL
    A0A5F8AS34
    Related
    ENSMMUP00000079715.1, ENSMMUT00000085662.1
    Conserved Domains (4) summary
    PLN02972
    Location:1071 → 1491
    PLN02972; Histidyl-tRNA synthetase
    cd14012
    Location:299 → 538
    PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cd14046
    Location:583 → 999
    STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    pfam05773
    Location:21 → 134
    RWD; RWD domain

  3. XM_015141919.2 → XP_014997405.2  eIF-2-alpha kinase GCN2 isoform X1

    UniProtKB/TrEMBL
    A0A5F8AGZ7, H9Z953
    Related
    ENSMMUP00000076222.1, ENSMMUT00000106710.1
    Conserved Domains (5) summary
    PLN02972
    Location:1071 → 1491
    PLN02972; Histidyl-tRNA synthetase
    cd14012
    Location:299 → 538
    PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cd14046
    Location:583 → 999
    STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    pfam05773
    Location:21 → 134
    RWD; RWD domain
    cl00266
    Location:1397 → 1641
    HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...

  4. XM_028850731.1 → XP_028706564.1  eIF-2-alpha kinase GCN2 isoform X3

    UniProtKB/TrEMBL
    A0A5F7ZNU9
    Related
    ENSMMUP00000066304.1, ENSMMUT00000093860.1
    Conserved Domains (5) summary
    smart00591
    Location:12 → 97
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    PLN02972
    Location:1031 → 1451
    PLN02972; Histidyl-tRNA synthetase
    cd14012
    Location:259 → 498
    PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cd14046
    Location:543 → 959
    STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cl00266
    Location:1357 → 1601
    HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...

RNA

  1. XR_001445839.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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