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KDM6A lysine demethylase 6A [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 100427119, updated on 17-Aug-2024

Summary

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Official Symbol
KDM6Aprovided by VGNC
Official Full Name
lysine demethylase 6Aprovided by VGNC
Primary source
VGNC:VGNC:73820
See related
Ensembl:ENSMMUG00000003317
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See KDM6A in Genome Data Viewer
Location:
chromosome: X
Exon count:
31
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) X NC_041774.1 (44781309..45018013)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) X NC_027913.1 (44961912..45197805)

Chromosome X - NC_041774.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114674935 Neighboring gene chromosome transmission fidelity protein 8 homolog pseudogene Neighboring gene dual specificity phosphatase 21 Neighboring gene divergent protein kinase domain 2B Neighboring gene plasmolipin pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K27me2/H3K27me3 demethylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lysine-specific demethylase 6A

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041774.1 Reference Mmul_10 Primary Assembly

    Range
    44781309..45018013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015127247.2 → XP_014982733.1  lysine-specific demethylase 6A isoform X1

    UniProtKB/TrEMBL
    A0A5F8AHK0, F7EHL1
    Related
    ENSMMUP00000004426.4, ENSMMUT00000004693.4
    Conserved Domains (4) summary
    smart00558
    Location:1151 → 1215
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:1185 → 1293
    JmjC; JmjC domain, hydroxylase

  2. XM_015127249.2 → XP_014982735.1  lysine-specific demethylase 6A isoform X3

    UniProtKB/TrEMBL
    H9FZD5, I2CV02
    Conserved Domains (4) summary
    pfam02373
    Location:1185 → 1293
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1151 → 1215
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]

  3. XM_015127248.2 → XP_014982734.1  lysine-specific demethylase 6A isoform X2

    UniProtKB/TrEMBL
    A0A5F8AHK0
    Conserved Domains (4) summary
    smart00558
    Location:1117 → 1181
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:1151 → 1259
    JmjC; JmjC domain, hydroxylase

  4. XM_015127252.2 → XP_014982738.1  lysine-specific demethylase 6A isoform X6

    UniProtKB/TrEMBL
    A0A1D5Q6W5, H9FZD5, I2CV02
    Related
    ENSMMUP00000043781.2, ENSMMUT00000075094.2
    Conserved Domains (5) summary
    pfam02373
    Location:1151 → 1259
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1117 → 1181
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    cl25496
    Location:430 → 788
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  5. XM_015127251.2 → XP_014982737.1  lysine-specific demethylase 6A isoform X5

    UniProtKB/TrEMBL
    H9FZD5, I2CV02
    Conserved Domains (4) summary
    smart00558
    Location:1099 → 1163
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:1133 → 1241
    JmjC; JmjC domain, hydroxylase

  6. XM_015127256.2 → XP_014982742.1  lysine-specific demethylase 6A isoform X10

    UniProtKB/TrEMBL
    A0A5F8A1Y9, H9FZD5, I2CV02
    Related
    ENSMMUP00000070911.1, ENSMMUT00000092809.1
    Conserved Domains (4) summary
    pfam02373
    Location:1133 → 1241
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1099 → 1163
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]

  7. XM_015127255.2 → XP_014982741.1  lysine-specific demethylase 6A isoform X9

    UniProtKB/TrEMBL
    H9FZD5, I2CV02
    Conserved Domains (4) summary
    smart00558
    Location:1065 → 1129
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:1099 → 1207
    JmjC; JmjC domain, hydroxylase

  8. XM_015127259.2 → XP_014982745.1  lysine-specific demethylase 6A isoform X13

    UniProtKB/TrEMBL
    H9FZD5, I2CV02
    Conserved Domains (5) summary
    pfam02373
    Location:1099 → 1207
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1065 → 1129
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    pfam15782
    Location:417 → 579
    GREB1; Gene regulated by oestrogen in breast cancer

  9. XM_015127250.2 → XP_014982736.1  lysine-specific demethylase 6A isoform X4

    UniProtKB/TrEMBL
    H9FZD5, I2CV02
    Conserved Domains (4) summary
    smart00558
    Location:1106 → 1170
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 401
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:1140 → 1248
    JmjC; JmjC domain, hydroxylase

  10. XM_015127254.2 → XP_014982740.1  lysine-specific demethylase 6A isoform X8

    UniProtKB/TrEMBL
    F7BRN8, H9FZD5, I2CV02
    Related
    ENSMMUP00000041109.3, ENSMMUT00000048072.3
    Conserved Domains (4) summary
    pfam02373
    Location:1140 → 1248
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1106 → 1170
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 401
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]

  11. XM_015127253.2 → XP_014982739.1  lysine-specific demethylase 6A isoform X7

    UniProtKB/TrEMBL
    H9FZD5, I2CV02
    Conserved Domains (4) summary
    smart00558
    Location:1072 → 1136
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 401
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:1106 → 1214
    JmjC; JmjC domain, hydroxylase

  12. XM_015127258.2 → XP_014982744.1  lysine-specific demethylase 6A isoform X12

    UniProtKB/TrEMBL
    H9FZD5, I2CV02
    Conserved Domains (6) summary
    pfam02373
    Location:1106 → 1214
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1072 → 1136
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:106 → 401
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:130 → 163
    TPR_1; Tetratricopeptide repeat
    pfam13431
    Location:272 → 303
    TPR_17; Tetratricopeptide repeat

  13. XM_015127257.2 → XP_014982743.1  lysine-specific demethylase 6A isoform X11

    UniProtKB/TrEMBL
    H9FZD5, I2CV02
    Conserved Domains (5) summary
    smart00558
    Location:1054 → 1118
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:47 → 315
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG4235
    Location:269 → 372
    NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:1088 → 1196
    JmjC; JmjC domain, hydroxylase

  14. XM_015127260.2 → XP_014982746.1  lysine-specific demethylase 6A isoform X14

    UniProtKB/TrEMBL
    A0A1D5QEA4, H9FZD5, I2CV02
    Related
    ENSMMUP00000046373.2, ENSMMUT00000055811.2
    Conserved Domains (5) summary
    pfam02373
    Location:1088 → 1196
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1054 → 1118
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:47 → 315
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    cl28296
    Location:269 → 372
    NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]

  15. XM_015127261.2 → XP_014982747.1  lysine-specific demethylase 6A isoform X15

    UniProtKB/TrEMBL
    H9FZD5, I2CV02
    Conserved Domains (5) summary
    pfam02373
    Location:1054 → 1162
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:1020 → 1084
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:47 → 315
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    cl28296
    Location:269 → 372
    NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]

RNA

  1. XR_001441950.2 RNA Sequence

  2. XR_003725955.1 RNA Sequence

Nucleotide Protein
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