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Ube2e1 ubiquitin-conjugating enzyme E2E 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100366017, updated on 4-Jan-2025

Summary

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Official Symbol
Ube2e1provided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2E 1provided by RGD
Primary source
RGD:2324438
See related
AllianceGenome:RGD:2324438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ISG15 transferase activity and ubiquitin conjugating enzyme activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and protein modification by small protein conjugation. Predicted to act upstream of or within protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human UBE2E1 (ubiquitin conjugating enzyme E2 E1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 128.8), Thymus (RPKM 128.1) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Ube2e1 in Genome Data Viewer
Location:
15p16
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (9870528..9924194)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (7439751..7493410)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (8124869..8178252)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon AGA) 36 Neighboring gene uncharacterized LOC134482081 Neighboring gene uncharacterized protein DDB_G0290685-like Neighboring gene NFKB inhibitor interacting Ras-like 1 Neighboring gene ribosomal protein L15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. Espinosa A, et al. Exp Cell Res, 2008 Dec 10. PMID 18845142
  2. A novel inflammation-induced ubiquitin E3 ligase in alveolar type II cells. Hu Y, et al. Biochem Biophys Res Commun, 2005 Jul 22. PMID 15936721
  3. Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. Takeuchi T, et al. J Biochem, 2005 Dec. PMID 16428300
  4. MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Nishito Y, et al. Biochem J, 2006 Jun 15. PMID 16522193, Free PMC Article
  5. Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Anan T, et al. Genes Cells, 1998 Nov. PMID 9990509

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ISG15 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ISG15 transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ISG15-protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ISG15-protein conjugation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 E1
NP_001386508.1
XP_038949665.1
XP_038949667.1
XP_038949668.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399579.1 → NP_001386508.1  ubiquitin-conjugating enzyme E2 E1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6K033, F1M3L4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    9870528..9924194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093740.2 → XP_038949668.1  ubiquitin-conjugating enzyme E2 E1 isoform X3

    Conserved Domains (1) summary
    pfam00179
    Location:14 → 151
    UQ_con; Ubiquitin-conjugating enzyme

  2. XM_039093737.2 → XP_038949665.1  ubiquitin-conjugating enzyme E2 E1 isoform X1

    Conserved Domains (2) summary
    PHA03378
    Location:19 → 108
    PHA03378; EBNA-3B; Provisional
    pfam00179
    Location:168 → 305
    UQ_con; Ubiquitin-conjugating enzyme

  3. XM_039093739.2 → XP_038949667.1  ubiquitin-conjugating enzyme E2 E1 isoform X2

    Conserved Domains (1) summary
    pfam00179
    Location:31 → 168
    UQ_con; Ubiquitin-conjugating enzyme
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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