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Rab37 RAB37, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 100364984, updated on 4-Jan-2025

Summary

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Official Symbol
Rab37provided by RGD
Official Full Name
RAB37, member RAS oncogene familyprovided by RGD
Primary source
RGD:2319982
See related
EnsemblRapid:ENSRNOG00000059793 AllianceGenome:RGD:2319982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in regulation of exocytosis. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment and secretory granule. Predicted to be active in Golgi apparatus and endosome. Orthologous to human RAB37 (RAB37, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 44.0), Spleen (RPKM 33.6) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rab37 in Genome Data Viewer
Location:
10q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (100833240..100900950)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100334639..100401974)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103643841..103711830)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693477 Neighboring gene transfer RNA alanine (anticodon AGC) 73 Neighboring gene Cd300 molecule-like family member F Neighboring gene NHERF family PDZ scaffold protein 1 Neighboring gene transmembrane protein 104 Neighboring gene N-acetyltransferase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37. Higashio H, et al. Sci Rep, 2016 Mar 2. PMID 26931073, Free PMC Article
  2. Rab37 is a novel mast cell specific GTPase localized to secretory granules. Masuda ES, et al. FEBS Lett, 2000 Mar 17. PMID 10722846
  3. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. Breuza L, et al. J Biol Chem, 2004 Nov 5. PMID 15308636
  4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAB37, member RAS oncogene family; ras-related protein Rab-37
Names
RAB37, member of RAS oncogene family
rCG35079-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430326.1 → NP_001417255.1  RAB37, member RAS oncogene family isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6ALE4

  2. NM_001430327.1 → NP_001417256.1  RAB37, member RAS oncogene family isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HKK7, D4A0G7

  3. NM_001430328.1 → NP_001417257.1  RAB37, member RAS oncogene family isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6AJ11, A6HKK4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    100833240..100900950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247775.5 → XP_006247837.1  ras-related protein Rab-37 isoform X2

    Related
    ENSRNOP00000092980.1, ENSRNOT00000120041.2
    Conserved Domains (2) summary
    smart00175
    Location:24 → 185
    RAB; Rab subfamily of small GTPases
    cd04112
    Location:23 → 213
    Rab26; Rab GTPase family 26 (Rab26)

  2. XM_039087796.2 → XP_038943724.1  ras-related protein Rab-37 isoform X3

    Conserved Domains (1) summary
    cl38936
    Location:31 → 163
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_008768408.4 → XP_008766630.1  ras-related protein Rab-37 isoform X1

    Related
    ENSRNOP00000071538.1, ENSRNOT00000086469.3
    Conserved Domains (2) summary
    smart00175
    Location:31 → 192
    RAB; Rab subfamily of small GTPases
    cd04112
    Location:31 → 220
    Rab26; Rab GTPase family 26 (Rab26)
Nucleotide Protein Strain
Heading Accession and Version

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