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Adgra2 adhesion G protein-coupled receptor A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100363275, updated on 27-Nov-2024

Summary

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Official Symbol
Adgra2provided by RGD
Official Full Name
adhesion G protein-coupled receptor A2provided by RGD
Primary source
RGD:2323365
See related
EnsemblRapid:ENSRNOG00000012991 AllianceGenome:RGD:2323365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr124
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; and sprouting angiogenesis. Predicted to act upstream of or within several processes, including negative regulation of vascular endothelial growth factor signaling pathway; positive regulation of endothelial cell migration; and regulation of establishment of blood-brain barrier. Predicted to be located in cell surface and intracellular membrane-bounded organelle. Predicted to be part of Wnt signalosome. Predicted to be active in plasma membrane. Orthologous to human ADGRA2 (adhesion G protein-coupled receptor A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 117.3), Uterus (RPKM 103.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adgra2 in Genome Data Viewer
Location:
16q12.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (71635814..71674275, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (64932964..64971433, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (69094587..69133015, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene RAB11 family interacting protein 1 Neighboring gene BRF2 general transcription factor 3B subunit Neighboring gene uncharacterized LOC134482405 Neighboring gene uncharacterized LOC134482406 Neighboring gene uncharacterized LOC120097504 Neighboring gene pyridoxal phosphate binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GPR124 induces NLRP3 inflammasome-mediated pyroptosis in endothelial cells during ischemic injury. Xu Y, et al. Eur J Pharmacol, 2024 Jan 5. PMID 38042462
  2. Possible involvement of orphan receptors GPR88 and GPR124 in the development of hypertension in spontaneously hypertensive rat. Calderón-Zamora L, et al. Clin Exp Hypertens, 2017. PMID 28678544
  3. Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Chang J, et al. Nat Med, 2017 Apr. PMID 28288111, Free PMC Article
  4. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Kuhnert F, et al. Science, 2010 Nov 12. PMID 21071672, Free PMC Article
  5. Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Cho C, et al. Neuron, 2017 Aug 30. PMID 28803732, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR124 induces NLRP3 inflammasome-mediated pyroptosis in endothelial cells during ischemic injury.
    Title: GPR124 induces NLRP3 inflammasome-mediated pyroptosis in endothelial cells during ischemic injury.
  2. Therefore, we conclude that GPR88 and GPR124 receptors may be involved in the development or maintenance of high blood pressure.
    Title: Possible involvement of orphan receptors GPR88 and GPR124 in the development of hypertension in spontaneously hypertensive rat.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of establishment of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of establishment of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Wnt signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Wnt signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor A2
Names
G protein-coupled receptor 124

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433282.1 → NP_001420211.1  adhesion G protein-coupled receptor A2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6IVY1

  2. NM_001433283.1 → NP_001420212.1  adhesion G protein-coupled receptor A2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    71635814..71674275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275883.1 → XP_063131953.1  adhesion G protein-coupled receptor A2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GIV5
    Related
    ENSRNOP00000090414.1, ENSRNOT00000109034.2

  2. XM_017600376.3 → XP_017455865.1  adhesion G protein-coupled receptor A2 isoform X2

    UniProtKB/TrEMBL
    D4ADC7
    Related
    ENSRNOP00000017776.6, ENSRNOT00000017776.7

  3. XM_003751617.6 → XP_003751665.2  adhesion G protein-coupled receptor A2 isoform X1

    Related
    ENSRNOP00000081432.2, ENSRNOT00000096010.2
    Conserved Domains (8) summary
    smart00082
    Location:234 → 267
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:130 → 208
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:130 → 151
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:299 → 385
    ig; Immunoglobulin domain
    pfam01825
    Location:750 → 791
    GPS; GPCR proteolysis site, GPS, motif
    pfam13855
    Location:130 → 186
    LRR_8; Leucine rich repeat
    cl02422
    Location:393 → 459
    HRM; Hormone receptor domain
    cl21561
    Location:817 → 985
    7tm_4; Olfactory receptor

  4. XM_006253295.5 → XP_006253357.1  adhesion G protein-coupled receptor A2 isoform X3

    Conserved Domains (8) summary
    smart00082
    Location:234 → 267
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:130 → 208
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:130 → 151
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:299 → 385
    ig; Immunoglobulin domain
    pfam01825
    Location:750 → 791
    GPS; GPCR proteolysis site, GPS, motif
    pfam13855
    Location:130 → 186
    LRR_8; Leucine rich repeat
    cl02422
    Location:393 → 459
    HRM; Hormone receptor domain
    cl21561
    Location:817 → 985
    7tm_4; Olfactory receptor

  5. XM_039095155.2 → XP_038951083.1  adhesion G protein-coupled receptor A2 isoform X5

    Conserved Domains (9) summary
    COG4886
    Location:118 → 349
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:130 → 151
    LRR_1; leucine-rich repeat [structural motif]
    pfam01825
    Location:750 → 791
    GPS; GPCR proteolysis site, GPS, motif
    pfam13855
    Location:130 → 186
    LRR_8; Leucine rich repeat
    cd00096
    Location:343 → 347
    Ig; Ig strand D [structural motif]
    cd14964
    Location:807 → 832
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02422
    Location:393 → 459
    HRM; Hormone receptor domain
    cl11960
    Location:338 → 385
    Ig; Immunoglobulin domain
    cl28897
    Location:805 → 876
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. XR_005494961.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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