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Epc1 enhancer of polycomb homolog 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100362678, updated on 9-Dec-2024

Summary

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Official Symbol
Epc1provided by RGD
Official Full Name
enhancer of polycomb homolog 1provided by RGD
Primary source
RGD:2324280
See related
EnsemblRapid:ENSRNOG00000014834 AllianceGenome:RGD:2324280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chromatin-protein adaptor activity and enzyme-substrate adaptor activity. Involved in vascular associated smooth muscle cell differentiation. Predicted to be located in nuclear body; nuclear membrane; and nucleolus. Predicted to be part of NuA4 histone acetyltransferase complex; nucleosome; and piccolo histone acetyltransferase complex. Predicted to be active in site of double-strand break. Orthologous to human EPC1 (enhancer of polycomb homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 163.9), Spleen (RPKM 127.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Epc1 in Genome Data Viewer
Location:
17q12.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (59198513..59289535, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (54503358..54594444, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (57303968..57394975, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene Histone deacetylase 1, pseudogene 12 Neighboring gene marker of proliferation Ki-67, pseudogene 1 Neighboring gene ral guanine nucleotide dissociation stimulator-like Neighboring gene family with sequence similarity 95 member C Neighboring gene ral guanine nucleotide dissociation stimulator-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enhancer of polycomb1 lessens neointima formation by potentiation of myocardin-induced smooth muscle differentiation. Joung H, et al. Atherosclerosis, 2012 May. PMID 22398275
  2. Enhancer of polycomb1 acts on serum response factor to regulate skeletal muscle differentiation. Kim JR, et al. J Biol Chem, 2009 Jun 12. PMID 19359245, Free PMC Article
  3. RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. Shimono Y, et al. J Biol Chem, 2000 Dec 15. PMID 10976108
  4. Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation. Kee HJ, et al. J Biol Chem, 2007 Mar 9. PMID 17192267
  5. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin-protein adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm DNA condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
involved_in vascular associated smooth muscle cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of piccolo histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of piccolo histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
enhancer of polycomb homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309462.1 → NP_001296391.1  enhancer of polycomb homolog 1

    See identical proteins and their annotated locations for NP_001296391.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I6GEL3, A6K9H9, D4A6E4
    Related
    ENSRNOP00000019968.7, ENSRNOT00000019968.9
    Conserved Domains (2) summary
    pfam06752
    Location:531 → 762
    E_Pc_C; Enhancer of Polycomb C-terminus
    pfam10513
    Location:1 → 98
    EPL1; Enhancer of polycomb-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    59198513..59289535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095281.2 → XP_038951209.1  enhancer of polycomb homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GEL3
    Conserved Domains (1) summary
    pfam06752
    Location:565 → 766
    E_Pc_C; Enhancer of Polycomb C-terminus

  2. XM_003751704.4 → XP_003751752.1  enhancer of polycomb homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_003751752.1

    UniProtKB/TrEMBL
    A0A8I6G2P8, A0A8I6GEL3
    Related
    ENSRNOP00000078400.1, ENSRNOT00000117368.2
    Conserved Domains (2) summary
    pfam06752
    Location:581 → 812
    E_Pc_C; Enhancer of Polycomb C-terminus
    pfam10513
    Location:7 → 148
    EPL1; Enhancer of polycomb-like

  3. XM_063276006.1 → XP_063132076.1  enhancer of polycomb homolog 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GEL3

  4. XM_039095280.2 → XP_038951208.1  enhancer of polycomb homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GEL3
    Conserved Domains (2) summary
    pfam06752
    Location:615 → 816
    E_Pc_C; Enhancer of Polycomb C-terminus
    pfam10513
    Location:7 → 148
    EPL1; Enhancer of polycomb-like

RNA

  1. XR_005495222.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001100972.1: Suppressed sequence

    Description
    NM_001100972.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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