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Otulin OTU deubiquitinase with linear linkage specificity [ Rattus norvegicus (Norway rat) ]

Gene ID: 100362554, updated on 9-Dec-2024

Summary

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Official Symbol
Otulinprovided by RGD
Official Full Name
OTU deubiquitinase with linear linkage specificityprovided by RGD
Primary source
RGD:2324500
See related
EnsemblRapid:ENSRNOG00000012017 AllianceGenome:RGD:2324500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam105b
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including protein linear deubiquitination; regulation of defense response; and regulation of signal transduction. Predicted to be part of LUBAC complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in otulipenia and primary immunodeficiency disease. Orthologous to human OTULIN (OTU deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 155.1), Liver (RPKM 128.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Otulin in Genome Data Viewer
Location:
2q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (80021381..80046898, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (78290437..78316633, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (80267724..80293204, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485723 Neighboring gene uncharacterized LOC120100754 Neighboring gene ANKH inorganic pyrophosphate transport regulator Neighboring gene OTU deubiquitinase with linear linkage specificity like Neighboring gene trio Rho guanine nucleotide exchange factor Neighboring gene uncharacterized LOC134485866

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-κB signalling pathway in acute ischaemic stroke rats. Xu H, et al. Mol Med, 2021 Apr 9. PMID 33836646, Free PMC Article
  2. OTULIN of exosomes derived from Schwann cells promotes peripheral nerve injury repair by regulating macrophage polarization via deubiquitination of ERBB2. Wang Y, et al. Neurosci Lett, 2024 Jun 11. PMID 38723761
  3. Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. Zhou Q, et al. Proc Natl Acad Sci U S A, 2016 Sep 6. PMID 27559085, Free PMC Article
  4. CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling. Hrdinka M, et al. Cell Rep, 2016 Mar 29. PMID 26997266, Free PMC Article
  5. OTULIN limits cell death and inflammation by deubiquitinating LUBAC. Heger K, et al. Nature, 2018 Jul. PMID 29950720

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OTULIN of exosomes derived from Schwann cells promotes peripheral nerve injury repair by regulating macrophage polarization via deubiquitination of ERBB2.
    Title: OTULIN of exosomes derived from Schwann cells promotes peripheral nerve injury repair by regulating macrophage polarization via deubiquitination of ERBB2.
  2. OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-kappaB signalling pathway in acute ischaemic stroke rats.
    Title: OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-κB signalling pathway in acute ischaemic stroke rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC187493

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein linear deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of LUBAC complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin thioesterase otulin
Names
family with sequence similarity 105, member B
NP_001289818.1
XP_006232150.1
XP_038957469.1
XP_038957470.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302889.1 → NP_001289818.1  ubiquitin thioesterase otulin

    See identical proteins and their annotated locations for NP_001289818.1

    Status: VALIDATED

    Source sequence(s)
    BC158613, BC158827, FM089678, FM122033, JAXUCZ010000002
    UniProtKB/TrEMBL
    B0BMY6
    Related
    ENSRNOP00000016111.4, ENSRNOT00000016111.6
    Conserved Domains (1) summary
    pfam16218
    Location:82 → 345
    Peptidase_C101; Peptidase family C101

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    80021381..80046898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232088.5 → XP_006232150.1  ubiquitin thioesterase otulin isoform X1

    See identical proteins and their annotated locations for XP_006232150.1

    UniProtKB/TrEMBL
    A6JMX8
    Conserved Domains (1) summary
    pfam16218
    Location:81 → 344
    Peptidase_C101; Peptidase family C101

  2. XM_039101541.2 → XP_038957469.1  ubiquitin thioesterase otulin isoform X2

    Conserved Domains (1) summary
    pfam16218
    Location:1 → 259
    Peptidase_C101; Peptidase family C101

  3. XM_039101542.2 → XP_038957470.1  ubiquitin thioesterase otulin isoform X2

    Conserved Domains (1) summary
    pfam16218
    Location:1 → 259
    Peptidase_C101; Peptidase family C101
Nucleotide Protein Strain
Heading Accession and Version

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