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Tmem276 Transmembrane protein 276 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100362155, updated on 4-Jan-2025

Summary

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Official Symbol
Tmem276provided by RGD
Official Full Name
Transmembrane protein 276provided by RGD
Primary source
RGD:2318728
See related
EnsemblRapid:ENSRNOG00000087425 AllianceGenome:RGD:2318728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable zinc ion binding activity. Predicted to be located in membrane. Predicted to be active in nucleus. Orthologous to human ZFTRAF1 (zinc finger TRAF-type containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 223.4), Heart (RPKM 163.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem276 in Genome Data Viewer
Location:
7q34
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110259212..110261096, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108378569..108380453, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117720909..117722734, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tonsoku-like, DNA repair protein Neighboring gene Tmem276-zftraf1 readthrough Neighboring gene zinc finger TRAF type containing 1 Neighboring gene kinesin family member C2 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1, regulatory subunit 16A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner. Menon RP, et al. FEBS Lett, 2000 Mar 31. PMID 10745073
  2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Readthrough Tmem276-zftraf1

Readthrough gene: Tmem276-zftraf1, Included gene: Zftraf1

Homology

Clone Names

  • MGC108816, MGC188650

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane protein 276

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025122.4 → NP_001020293.2  transmembrane protein 276 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    F1M4N0, P0DW88, Q5BK76

  2. NM_001408118.1 → NP_001395047.1  transmembrane protein 276 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    F1M4N0, P0DW88, Q5BK76

  3. NM_001408119.2 → NP_001395048.1  transmembrane protein 276 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    Related
    ENSRNOP00000019876.4, ENSRNOT00000019876.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    110259212..110261096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DW88.1 GenPept UniProtKB/Swiss-Prot:P0DW88

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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