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Psmg3 proteasome assembly chaperone 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100361517, updated on 27-Nov-2024

Summary

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Official Symbol
Psmg3provided by RGD
Official Full Name
proteasome assembly chaperone 3provided by RGD
Primary source
RGD:2319950
See related
EnsemblRapid:ENSRNOG00000001273 AllianceGenome:RGD:2319950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305593
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in chaperone-mediated protein complex assembly. Predicted to be part of protein-containing complex. Orthologous to human PSMG3 (proteasome assembly chaperone 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 74.8), Brain (RPKM 73.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Psmg3 in Genome Data Viewer
Location:
12q11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19923288..19926205)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14809440..14812357)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16898999..16901945)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene mitotic arrest deficient 1 like 1 Neighboring gene uncharacterized LOC134481158 Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC102546414 Neighboring gene transmembrane protein 184A Neighboring gene MAF bZIP transcription factor K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PAC1-PAC2 proteasome assembly chaperone retains the core α4-α7 assembly intermediates in the cytoplasm. Wu W, et al. Genes Cells, 2018 Oct. PMID 30133132
  2. Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. Hirano Y, et al. Mol Cell, 2006 Dec 28. PMID 17189198
  3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  4. 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Le Tallec B, et al. Mol Cell, 2007 Aug 17. PMID 17707236
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proteasome assembly chaperone 3
Names
proteasome (prosome, macropain) assembly chaperone 3
proteasome (prosome, macropain) assembly chaperone 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399013.1 → NP_001385942.1  proteasome assembly chaperone 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6K1T8, D3ZIU2
    Conserved Domains (1) summary
    pfam10178
    Location:34 → 119
    PAC3; Proteasome assembly chaperone 3

  2. NM_001399014.1 → NP_001385943.1  proteasome assembly chaperone 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6K1T8, D3ZIU2
    Related
    ENSRNOP00000001716.4, ENSRNOT00000001716.9
    Conserved Domains (1) summary
    pfam10178
    Location:34 → 119
    PAC3; Proteasome assembly chaperone 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    19923288..19926205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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