Angptl8 angiopoietin-like 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Angptl8provided by RGD
Official Full Name: angiopoietin-like 8provided by RGD
Primary source: RGD:2320121
See related: EnsemblRapid:ENSRNOG00000011490 AllianceGenome:RGD:2320121
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in cellular lipid metabolic process; regulation of lipid metabolic process; and triglyceride homeostasis. Predicted to act upstream of or within cell maturation; fat cell differentiation; and regulation of protein metabolic process. Predicted to be active in extracellular region. Orthologous to human ANGPTL8 (angiopoietin like 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 136.4), Adrenal (RPKM 59.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (28652555..28654581)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (20376462..20378488)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (22855495..22858565)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of irisin and exercise on adropin and betatrophin in a new metabolic syndrome model.
Title: Effects of irisin and exercise on adropin and betatrophin in a new metabolic syndrome model.
These results suggest that early administration of betatrophin promotes betacell proliferation in STZinduced diabetic neonates and prevents the development of diabetes in adults.
Title: Recombinant betatrophin (Angptl‑8/lipasin) ameliorates streptozotocin‑induced hyperglycemia and β‑cell destruction in neonatal rats.
A significant increase in the serum concentration of irisin (p < 0.05), betatrophin (p < 0.05), and insulin (p < 0.001) and significant decrease in the FBG (P < 0.01) and lipid profiles (p < 0.01) were observed.
Title: High-intensity interval training improved fasting blood glucose and lipid profiles in type 2 diabetic rats more than endurance training; possible involvement of irisin and betatrophin.
Angptl8 KO in rats resulted in lower body weight and plasma TG levels without affecting glucose metabolism
Title: CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma triglyceride concentrations and adiposity in rats.
ANGPTL8 induced adult and aged beta cell regeneration in a rat model.
Title: In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

BI274505 (e-PCR)
- UniSTS:249119

BI282731 (e-PCR)
- UniSTS:249832

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
NOT involved_in glucose metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
NOT involved_in type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiopoietin-like protein 8

Names: betatrophin; lipasin; rCG31799-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.