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Fhod3 formin homology 2 domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100360334, updated on 27-Nov-2024

Summary

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Official Symbol
Fhod3provided by RGD
Official Full Name
formin homology 2 domain containing 3provided by RGD
Primary source
RGD:2322319
See related
EnsemblRapid:ENSRNOG00000027230 AllianceGenome:RGD:2322319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity. Acts upstream of or within sarcomere organization. Located in striated muscle thin filament. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human FHOD3 (formin homology 2 domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007906026.1 and NW_007906027.1 in NCBI's Rattus norvegicus Annotation Release 105. [19 Jun 2015]
Expression
Biased expression in Heart (RPKM 565.8), Muscle (RPKM 151.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fhod3 in Genome Data Viewer
Location:
18p12
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (16267830..16700508)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (15993079..16425796)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (16650786..17332209)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 2 Neighboring gene molybdenum cofactor sulfurase Neighboring gene uncharacterized LOC120098112 Neighboring gene uncharacterized LOC134482922 Neighboring gene heat shock cognate protein 70, pseudogene 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene tubulin polyglutamylase complex subunit 2 Neighboring gene KIAA1328 homolog Neighboring gene CUGBP, Elav-like family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mechanical confinement triggers glioma linear migration dependent on formin FHOD3. Monzo P, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912794, Free PMC Article
  2. Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis. Kan-O M, et al. Biol Open, 2012 Sep 15. PMID 23213483, Free PMC Article
  3. Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heart. Kan-o M, et al. PLoS One, 2012. PMID 22509354, Free PMC Article
  4. Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles. Taniguchi K, et al. J Biol Chem, 2009 Oct 23. PMID 19706596, Free PMC Article
  5. Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor. Arimura T, et al. Circ J, 2013. PMID 24088304

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FHOD3 played a role in glioma linear migration.
    Title: Mechanical confinement triggers glioma linear migration dependent on formin FHOD3.
  2. DCM-associated FHOD3 variant may cause DCM by interfering with actin filament assembly.
    Title: Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor.
  3. Following myofibril disassembly, such as that in dedifferentiating adult rat cardiomyocytes in culture, the expression of non-muscle Fhod3 is up-regulated, which is reversed once the myofibrils are reassembled.
    Title: Two distinct phosphorylation events govern the function of muscle FHOD3.
  4. actin dynamics regulated by Fhod3 are critical for sarcomere organization in striated muscle cells.
    Title: Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cardiac myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cardiac myofibril assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sarcomere organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
FH1/FH2 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271332.3 → NP_001258261.3  FH1/FH2 domain-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    F1LQJ2

  2. NM_001415718.1 → NP_001402647.1  FH1/FH2 domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I5ZR39
    Related
    ENSRNOP00000080632.1, ENSRNOT00000102032.2

  3. NM_001415719.1 → NP_001402648.1  FH1/FH2 domain-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018

  4. NM_001415720.1 → NP_001402649.1  FH1/FH2 domain-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    F1LRX2
    Related
    ENSRNOP00000061693.3, ENSRNOT00000068139.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    16267830..16700508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600804.3 → XP_017456293.1  FH1/FH2 domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A1W2Q6D5, A6J2L1
    Related
    ENSRNOP00000076213.2, ENSRNOT00000093679.3

  2. XM_017600806.3 → XP_017456295.1  FH1/FH2 domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    A6J2L1

  3. XM_063277043.1 → XP_063133113.1  FH1/FH2 domain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A1W2Q659
    Related
    ENSRNOP00000076142.2, ENSRNOT00000093285.3
Nucleotide Protein Strain
Heading Accession and Version

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