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Vti1b vesicle transport through interaction with t-SNAREs 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 100359512, updated on 4-Jan-2025

Summary

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Official Symbol
Vti1bprovided by RGD
Official Full Name
vesicle transport through interaction with t-SNAREs 1Bprovided by RGD
Primary source
RGD:2323682
See related
EnsemblRapid:ENSRNOG00000060436 AllianceGenome:RGD:2323682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Vti1l1; Vti1-rp1; RGD1560475
Summary
Predicted to enable SNAP receptor activity; SNARE binding activity; and chloride channel inhibitor activity. Predicted to be involved in several processes, including Golgi vesicle transport; regulation of protein localization to plasma membrane; and retrograde transport, endosome to Golgi. Located in neuronal cell body and synaptic vesicle. Part of SNARE complex. Is active in presynaptic endosome membrane. Orthologous to human VTI1B (vesicle transport through interaction with t-SNAREs 1B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 241.7), Brain (RPKM 222.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Vti1b in Genome Data Viewer
Location:
6q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (103694342..103709544, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (97957700..97976491, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (102340261..102353612, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class H Neighboring gene branched chain ketoacid dehydrogenase kinase, pseudogene 1 Neighboring gene arginase 2 Neighboring gene retinol dehydrogenase 11 Neighboring gene androgen-dependent TFPI-regulating protein, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles. Miller SE, et al. Nature, 2007 Nov 22. PMID 18033301
  2. The SNARE Vti1a-beta is localized to small synaptic vesicles and participates in a novel SNARE complex. Antonin W, et al. J Neurosci, 2000 Aug 1. PMID 10908612, Free PMC Article
  3. Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport. Nakajima K, et al. Mol Cell Biol, 2002 Feb. PMID 11784862, Free PMC Article
  4. Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events. Pryor PR, et al. EMBO Rep, 2004 Jun. PMID 15133481, Free PMC Article
  5. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Itakura E, et al. Cell, 2012 Dec 7. PMID 23217709

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
  
enables chloride channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables chloride channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion with Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic endosome membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vesicle transport through interaction with t-SNAREs homolog 1B
Names
Vesicle transport v-SNARE protein Vti1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377194.1 → NP_001364123.1  vesicle transport through interaction with t-SNAREs homolog 1B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6GJ34, F1LNC4
    Conserved Domains (2) summary
    cd15890
    Location:136 → 197
    SNARE_Vti1b; SNARE motif of Vti1b-like
    pfam05008
    Location:18 → 96
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    103694342..103709544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111590.2 → XP_038967518.1  vesicle transport through interaction with t-SNAREs homolog 1B isoform X1

    UniProtKB/Swiss-Prot
    P58200
    UniProtKB/TrEMBL
    A6HCG5
    Related
    ENSRNOP00000070613.2, ENSRNOT00000090407.3
    Conserved Domains (2) summary
    cd15890
    Location:136 → 197
    SNARE_Vti1b; SNARE motif of Vti1b-like
    pfam05008
    Location:18 → 96
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  2. XM_039111592.2 → XP_038967520.1  vesicle transport through interaction with t-SNAREs homolog 1B isoform X2

    Conserved Domains (2) summary
    cd15890
    Location:75 → 136
    SNARE_Vti1b; SNARE motif of Vti1b-like
    pfam05008
    Location:1 → 35
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  3. XM_039111591.2 → XP_038967519.1  vesicle transport through interaction with t-SNAREs homolog 1B isoform X2

    Conserved Domains (2) summary
    cd15890
    Location:75 → 136
    SNARE_Vti1b; SNARE motif of Vti1b-like
    pfam05008
    Location:1 → 35
    V-SNARE; Vesicle transport v-SNARE protein N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58200.2 GenPept UniProtKB/Swiss-Prot:P58200

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