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acvr2ab activin A receptor type 2Ab [ Danio rerio (zebrafish) ]

Gene ID: 100331014, updated on 4-Jan-2025

Summary

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Official Symbol
acvr2abprovided by ZNC
Official Full Name
activin A receptor type 2Abprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120215-23
See related
Ensembl:ENSDARG00000104700 AllianceGenome:ZFIN:ZDB-GENE-120215-23
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-264o13.1
Summary
Predicted to enable activin binding activity and activin receptor activity. Predicted to be involved in activin receptor signaling pathway; cellular response to growth factor stimulus; and pattern specification process. Predicted to act upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway and protein phosphorylation. Predicted to be located in membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Lynch syndrome and colon cancer. Orthologous to human ACVR2A (activin A receptor type 2A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See acvr2ab in Genome Data Viewer
Location:
chromosome: 6
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (1724723..1744228)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (870303..891740)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495830 Neighboring gene uncharacterized LOC137495831 Neighboring gene origin recognition complex, subunit 4 Neighboring gene zgc:158417

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1(R206H) -Specific Human Cellular and Zebrafish Models. Wentworth KL, et al. J Bone Miner Res, 2022 Nov. PMID 36153796, Free PMC Article
  2. Transcriptomic Interaction between Young Fecal Transplantation and Perfluorobutanesulfonate in Aged Zebrafish Gonads. Tang L, et al. Toxics, 2022 Oct 22. PMID 36355923, Free PMC Article
  3. Functional comparison of human ACVR1 and zebrafish Acvr1l FOP-associated variants in embryonic zebrafish. Lalonde RL, et al. Dev Dyn, 2023 May. PMID 36606464, Free PMC Article
  4. Regulation of Nodal signaling propagation by receptor interactions and positive feedback. Preiß H, et al. Elife, 2022 Sep 23. PMID 36149406, Free PMC Article
  5. Genetic evidence for Amh modulation of gonadotropin actions to control gonadal homeostasis and gametogenesis in zebrafish and its noncanonical signaling through Bmpr2a receptor. Zhang Z, et al. Development, 2020 Nov 29. PMID 33060133

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables activin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables activin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
activin receptor type-2A
Names
activin A receptor, type IIAb

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    1724723..1744228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168700.5 → XP_005168757.1  activin receptor type-2A isoform X2

    UniProtKB/TrEMBL
    A0A8M2BGK0
    Conserved Domains (3) summary
    smart00220
    Location:125 → 397
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14053
    Location:121 → 410
    STKc_ACVR2; Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor
    pfam01064
    Location:1 → 45
    Activin_recp; Activin types I and II receptor domain

  2. XM_009302086.4 → XP_009300361.1  activin receptor type-2A isoform X1

    UniProtKB/TrEMBL
    A0A0R4ISZ9, A0A8M3B327
    Related
    ENSDARP00000139057.2, ENSDART00000157415.2
    Conserved Domains (3) summary
    smart00220
    Location:126 → 398
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14053
    Location:122 → 411
    STKc_ACVR2; Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor
    pfam01064
    Location:1 → 46
    Activin_recp; Activin types I and II receptor domain
Nucleotide Protein
Heading Accession and Version

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