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bcl11bb BCL11 transcription factor B b [ Danio rerio (zebrafish) ]

Gene ID: 100330974, updated on 9-Dec-2024

Summary

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Official Symbol
bcl11bbprovided by ZNC
Official Full Name
BCL11 transcription factor B bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110201-2
See related
Ensembl:ENSDARG00000116556 AllianceGenome:ZFIN:ZDB-GENE-110201-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
bcl11b.2; im:7142702
Summary
Predicted to enable metal ion binding activity. Predicted to be located in nucleus. Is expressed in brain and thymus. Human ortholog(s) of this gene implicated in immunodeficiency 49. Orthologous to human BCL11B (BCL11 transcription factor B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See bcl11bb in Genome Data Viewer
Location:
chromosome: 20
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (4393264..4455777)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (4222035..4285532)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene rho guanine nucleotide exchange factor TIAM2 Neighboring gene uncharacterized LOC137488609 Neighboring gene claudin-20 Neighboring gene uncharacterized LOC137488610 Neighboring gene poly(A) polymerase alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of genetic networks underlying the emergence of thymopoiesis in vertebrates. Bajoghli B, et al. Cell, 2009 Jul 10. PMID 19559469
  2. Insm1a-mediated gene repression is essential for the formation and differentiation of Müller glia-derived progenitors in the injured retina. Ramachandran R, et al. Nat Cell Biol, 2012 Oct. PMID 23000964, Free PMC Article
  3. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
B-cell lymphoma/leukemia 11B
Names
BAF chromatin remodeling complex subunit BCL11B b

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    4393264..4455777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002667860.7 → XP_002667906.3  B-cell lymphoma/leukemia 11B

    UniProtKB/TrEMBL
    A0A2R8QLP7, A0A8M1RN44
    Related
    ENSDARP00000153465.1, ENSDART00000187271.1
    Conserved Domains (3) summary
    sd00017
    Location:698 → 718
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:697 → 718
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:710 → 735
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases
Research Materials