rock1 Rho-associated, coiled-coil containing protein kinase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rock1provided by ZNC
Official Full Name: Rho-associated, coiled-coil containing protein kinase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-100712-2
See related: Ensembl:ENSDARG00000058993 AllianceGenome:ZFIN:ZDB-GENE-100712-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable Rho-dependent protein serine/threonine kinase activity. Involved in epicardial cell to mesenchymal cell transition; negative regulation of adherens junction organization; and positive regulation of stress fiber assembly. Acts upstream of or within regulation of cytoskeleton organization. Predicted to be located in several cellular components, including bleb; centriole; and ruffle. Predicted to be active in cytoplasmic stress granule and cytoskeleton. Is expressed in forebrain and hindbrain. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (2818643..2900825)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (2976746..3058926)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin alpha2-I Domain-Collagen Complex Formation and RhoA/ROCK1 Signaling.
Title: Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin α2-I Domain-Collagen Complex Formation and RhoA/ROCK1 Signaling.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in epicardial cell to mesenchymal cell transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in bleb	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho-associated protein kinase 1

Names: rho-associated coiled-coil domain-containing protein kinase 1

NP_001243563.1

EC 2.7.11.1

XP_021334267.1

EC 2.7.11.1

XP_068078897.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256634.1 → NP_001243563.1 rho-associated protein kinase 1

See identical proteins and their annotated locations for NP_001243563.1

Status: PROVISIONAL

Source sequence(s)

JN416777

UniProtKB/TrEMBL

A0A0R4IVY5, E7F9X9, H6U1H5

Related

ENSDARP00000141411.2, ENSDART00000163587.2

Conserved Domains (7) summary

cd11639
Location:493 → 558

HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1

smart00220
Location:78 → 340

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1196
Location:426 → 1105

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1234 → 1288

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01242
Location:1124 → 1230

PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain

cd05622
Location:4 → 408

STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1

pfam08912
Location:952 → 1017

Rho_Binding; Rho Binding

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

2818643..2900825

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021478592.2 → XP_021334267.1 rho-associated protein kinase 1 isoform X1

UniProtKB/TrEMBL

A0A8M9PRV2

Conserved Domains (4) summary

cd00029
Location:1234 → 1288

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01242
Location:1124 → 1230

PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain

cd05622
Location:4 → 408

STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1

cl25732
Location:426 → 1105

SMC_N; RecF/RecN/SMC N terminal domain
XM_068222796.1 → XP_068078897.1 rho-associated protein kinase 1 isoform X2