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farp1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) [ Danio rerio (zebrafish) ]

Gene ID: 100329707, updated on 4-Jan-2025

Summary

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Official Symbol
farp1provided by ZNC
Official Full Name
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)provided by ZNC
Primary source
ZFIN:ZDB-GENE-070424-163
See related
Ensembl:ENSDARG00000074381 AllianceGenome:ZFIN:ZDB-GENE-070424-163
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-235f1.1
Summary
Predicted to enable phosphatidylinositol phosphate binding activity and phosphatidylserine binding activity. Acts upstream of or within glomerular filtration. Predicted to be located in several cellular components, including cytosol; dendritic spine; and filopodium. Orthologous to human FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See farp1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (2301955..2446117)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (2154136..2296358)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495389 Neighboring gene small nucleolar RNA SNORA84 Neighboring gene karyopherin (importin) beta 3 Neighboring gene si:ch211-235f1.3 Neighboring gene gamma-glutamylamine cyclotransferase, tandem duplicate 3 Neighboring gene gamma-glutamylamine cyclotransferase, tandem duplicate 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Structural analyses of FERM domain-mediated membrane localization of FARP1. Kuo YC, et al. Sci Rep, 2018 Jul 11. PMID 29992992, Free PMC Article
  2. A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Rinschen MM, et al. Cell Rep, 2018 May 22. PMID 29791858, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphatidylinositol phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within glomerular filtration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FERM, ARHGEF and pleckstrin domain-containing protein 1
Names
FERM, RhoGEF and pleckstrin domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    2301955..2446117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017355952.3 → XP_017211441.1  FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z6P5, E9QIC8

  2. XM_068220984.1 → XP_068077085.1  FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    E9QIC8

  3. XM_068220985.1 → XP_068077086.1  FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    E9QIC8
    Related
    ENSDARP00000113717.1, ENSDART00000142944.2
Nucleotide Protein Strain
Heading Accession and Version

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