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magi1a membrane associated guanylate kinase, WW and PDZ domain containing 1a [ Danio rerio (zebrafish) ]

Gene ID: 100319849, updated on 9-Dec-2024

Summary

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Official Symbol
magi1aprovided by ZNC
Official Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081105-13
See related
Ensembl:ENSDARG00000070145 AllianceGenome:ZFIN:ZDB-GENE-081105-13
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch1073-268b21.1
Summary
Predicted to enable kinase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be located in membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See magi1a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (54054702..54075090)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (53645587..53667665)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene sushi domain-containing protein 3 Neighboring gene serine/threonine-protein kinase WNK2 Neighboring gene prickle homolog 2a Neighboring gene rhodopsin Neighboring gene uncharacterized LOC100332221

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Analysis of protein expression in zebrafish during gonad differentiation by targeted proteomics. Groh KJ, et al. Gen Comp Endocrinol, 2013 Nov 1. PMID 23968773
  2. A draft genome of the striped catfish, Pangasianodon hypophthalmus, for comparative analysis of genes relevant to development and a resource for aquaculture improvement. Kim OTP, et al. BMC Genomics, 2018 Oct 5. PMID 30290758, Free PMC Article
  3. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Trinh le A, et al. Genes Dev, 2011 Nov 1. PMID 22056673, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    54054702..54075090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478525.1 → XP_021334200.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QAB3, A0A8M9QJB9
    Conserved Domains (8) summary
    smart00228
    Location:434 → 515
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:264 → 293
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:956 → 1051
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:322 → 351
    WW; WW domain
    pfam04484
    Location:1303 → 1483
    DUF566; Family of unknown function (DUF566)
    pfam16663
    Location:175 → 219
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:692 → 787
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:95 → 166
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. XM_068223244.1 → XP_068079345.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QAB3

  3. XM_068223245.1 → XP_068079346.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q456
    Related
    ENSDARP00000093471.4, ENSDART00000102696.5

  4. XM_068223246.1 → XP_068079347.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q456, A0A8M9QAC5
Nucleotide Protein
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