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Mir214 microRNA 214 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100314055, updated on 2-Nov-2024

Summary

Official Symbol
Mir214provided by RGD
Official Full Name
microRNA 214provided by RGD
Primary source
RGD:2325548
See related
EnsemblRapid:ENSRNOG00000035513 miRBase:MI0000954; AllianceGenome:RGD:2325548
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rno-mir-214
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See Mir214 in Genome Data Viewer
Location:
13q22
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (77121645..77121752)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (74588374..74588481)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (80130905..80131014)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene dynamin 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene microRNA 199a-2 Neighboring gene microRNA 3120 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102554073

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Other Names

  • microRNA mir-214

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA base-pairing translational repressor activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell dedifferentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxygen levels ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within type B pancreatic cell development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_031927.2 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000013
    Related
    ENSRNOT00000053636.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    77121645..77121752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)