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Mir10a microRNA 10a [ Rattus norvegicus (Norway rat) ]

Gene ID: 100313996, updated on 2-Nov-2024

Summary

Official Symbol
Mir10aprovided by RGD
Official Full Name
microRNA 10aprovided by RGD
Primary source
RGD:2325601
See related
EnsemblRapid:ENSRNOG00000035535 miRBase:MI0000841; AllianceGenome:RGD:2325601
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rno-mir-10a
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See Mir10a in Genome Data Viewer
Location:
10q26
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81779709..81779818)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81283171..81283280)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84165950..84166059)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene homeobox B5 and homeobox B6, opposite strand Neighboring gene homeo box B6 Neighboring gene homeo box B5 Neighboring gene homeo box B4 Neighboring gene homeo box B3 Neighboring gene uncharacterized LOC102550580

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Other Names

  • microRNA mir-10a

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA base-pairing translational repressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to ethanol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxygen levels ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_031814.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    Related
    ENSRNOT00000053658.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    81779709..81779818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)