smo.L smoothened, frizzled class receptor L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: smo.L
Official Full Name: smoothened, frizzled class receptor L homeolog
Primary source: Xenbase:XB-GENE-487424
Locus tag: XELAEV_18017905mg
See related: EnsemblRapid:ENSXLAG00005023632 AllianceGenome:Xenbase:XB-GENE-487424
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: smo; XSmo; smoothened
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; Wnt signaling pathway; and tissue development. Predicted to be located in cilium and plasma membrane. Is expressed in anatomical system; mesenchyme; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; malignant pleural mesothelioma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 3L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (92901374..92929594, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (77577165..77605510, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane bounded cell projection	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: smoothened, frizzled class receptor L homeolog

Names: X-smoothened; smoothened homolog; smoothened, frizzled family receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135232.1 → NP_001128704.1 smoothened, frizzled class receptor L homeolog precursor

See identical proteins and their annotated locations for NP_001128704.1

Status: PROVISIONAL

Source sequence(s)

BC168525

UniProtKB/TrEMBL

A0A974HT42, B5DE47

Related

ENSXLAP00005069959.1, ENSXLAT00005071494.1

Conserved Domains (2) summary

cd07451
Location:39 → 169

CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein

pfam01534
Location:194 → 523

Frizzled; Frizzled/Smoothened family membrane region

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

92901374..92929594 complement

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GenBank, FASTA, Sequence Viewer (Graphics)