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si:ch211-74m13.1 si:ch211-74m13.1 [ Danio rerio (zebrafish) ]

Gene ID: 100149459, updated on 27-Dec-2024

Summary

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Official Symbol
si:ch211-74m13.1provided by ZNC
Official Full Name
si:ch211-74m13.1provided by ZNC
Primary source
ZFIN:ZDB-GENE-081104-12
See related
Ensembl:ENSDARG00000095312 AllianceGenome:ZFIN:ZDB-GENE-081104-12
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable integrin binding activity. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Orthologous to human ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See si:ch211-74m13.1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (54776171..54792813)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (54521619..54537304)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene intercellular adhesion molecule 3 Neighboring gene intercellular adhesion molecule 2 Neighboring gene UBA-like domain containing 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability. Wang L, et al. Dis Model Mech, 2021 Nov 1. PMID 34542605, Free PMC Article
  2. Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells. Hsieh FC, et al. Sci Rep, 2018 May 18. PMID 29777134, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
intercellular adhesion molecule 1; intercellular adhesion molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    54776171..54792813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068219441.1 → XP_068075542.1  intercellular adhesion molecule 2 isoform X1

  2. XM_001921980.8 → XP_001922015.4  intercellular adhesion molecule 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M1QR11, F6PEJ8
    Related
    ENSDARP00000116079.2, ENSDART00000142710.3
    Conserved Domains (3) summary
    cd05755
    Location:109 → 209
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    smart00410
    Location:230 → 281
    IG_like; Immunoglobulin like
    pfam13895
    Location:217 → 281
    Ig_2; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version

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